NP_037365
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,937 Da
NCBI Official Full Name
STE20/SPS1-related proline-alanine-rich protein kinase
NCBI Official Synonym Full Names
serine threonine kinase 39
NCBI Protein Information
STE20/SPS1-related proline-alanine-rich protein kinase
UniProt Protein Name
STE20/SPS1-related proline-alanine-rich protein kinase
UniProt Synonym Protein Names
DCHT; Serine/threonine-protein kinase 39
UniProt Synonym Gene Names
UniProt Entry Name
STK39_HUMAN
NCBI Summary for Stk39
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008]
UniProt Comments for Stk39
STLK3: May act as a mediator of stress-activated signals. The phosphorylated form forms a complex with WNK2. Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, STE; STE group; STE20 family; FRAY subfamily
Chromosomal Location of Human Ortholog: 2q24.3
Cellular Component: cytoskeleton; basolateral plasma membrane; apical plasma membrane; cytoplasm; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; protein kinase binding; ATP binding; receptor signaling protein serine/threonine kinase activity
Biological Process: peptidyl-serine phosphorylation; regulation of inflammatory response; positive regulation of potassium ion transport; peptidyl-threonine phosphorylation; response to stress; protein amino acid phosphorylation
Research Articles on Stk39
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Products associated with anti-Stk39 antibody
Pathways associated with anti-Stk39 antibody
Diseases associated with anti-Stk39 antibody
Organs/Tissues associated with anti-Stk39 antibody
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