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anti-SNCA antibody :: Rabbit Synuclein Polyclonal Antibody

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Catalog # MBS9502552
Unit / Price
  0.05 mg  /  $225 +1 FREE 8GB USB
  0.1 mg  /  $310 +1 FREE 8GB USB
Product Name

Synuclein (SNCA), Polyclonal Antibody

Popular Item
Also Known As

Synuclein (Phospho-Ser129) Antibody

Product Synonym Names
Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP; SNCA; NACP; PARK1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
126
OMIM
L08850 mRNA
3D Structure
ModBase 3D Structure for P37840
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
Synuclein (Phospho-Ser129) Antibody detects endogenous levels of Synuclein only when phosphorylated at Ser129.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho peptide.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Phospho
Modification Sites
H:S129; M:S129; R:S129
Immunogen
The antiserum was produced against synthesized peptide derived from human Synuclein around the phosphorylation site of Ser129.
Immunogen Range
91-140
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-SNCA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SNCA antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-SNCA antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:1000

Immunohistochemistry (IHC) of anti-SNCA antibody
Immunohistochemistry analysis of paraffin-embedded human brain, using Synuclein (Phospho-Ser129) Antibody. The picture on the right is blocked with the phospho peptide.
anti-SNCA antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-SNCA antibody
Western blot analysis of lysates from mouse brain, using Synuclein (Phospho-Ser129) Antibody. The lane on the right is blocked with the phospho peptide.
anti-SNCA antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for SNCA. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14 kDa
NCBI Official Full Name
alpha-synuclein isoform NACP140
NCBI Official Synonym Full Names
synuclein alpha
NCBI Official Symbol
NCBI Official Synonym Symbols
PD1; NACP; PARK1; PARK4
  [Similar Products]
NCBI Protein Information
alpha-synuclein
UniProt Protein Name
Alpha-synuclein
UniProt Synonym Protein Names
Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
NACP; PARK1; NACP  [Similar Products]
NCBI Summary for SNCA
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
UniProt Comments for SNCA
May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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