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anti-MAL antibody :: Goat T-cell differentiation protein Polyclonal Antibody

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Catalog # MBS420881
Unit / Price
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  0.1 mg  /  $225 +1 FREE 8GB USB
anti-MAL antibody
Product Name

T-cell differentiation protein (MAL), Polyclonal Antibody

Full Product Name

Goat anti-T-cell differentiation protein Antibody

Product Synonym Names
MAL; mal, T-cell differentiation protein; T-cell differentiation protein MAL; T-lymphocyte maturation-associated protein; myelin and lymphocyte protein; MAL antibody; mal; T-cell differentiation protein antibody; T-cell differentiation protein MAL antibody; T-lymphocyte maturation-associated protein antibody; myelin and lymphocyte protein antibody; T-cell differentiation protein; T-cell differentiation protein
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
QDGFTYRHYH EN
OMIM
188860
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human, Mouse, Rat
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-QDGFTYRHYHEN, from the internal region of the protein sequence according to NP_002362.1; NP_071884.1.
Epitope
Internal region
Note
This antibody is expected to recognise isoform a (NP_002362.1) and isoform c (NP_071884.1).
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-MAL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-MAL antibody
Peptide ELISA (EIA)
Application Notes for anti-MAL antibody
Peptide ELISA: Antibody detection limit dilution 1: 4000.
Western Blot: Preliminary experiments gave an approx 35kDa band in Human Thymus and Thyroid Gland lysates after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 16.7kDa according to NP_002362.1. The 35kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI/Uniprot data below describe general gene information for MAL. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Manufactured in an ISO 9001:2015 Certified Laboratory.NP_071884.1[Other Products]
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
5,989 Da
NCBI Official Full Name
myelin and lymphocyte protein isoform a
NCBI Official Synonym Full Names
mal, T-cell differentiation protein
NCBI Official Symbol
NCBI Protein Information
myelin and lymphocyte protein
UniProt Protein Name
Myelin and lymphocyte protein
UniProt Synonym Protein Names
T-lymphocyte maturation-associated protein
UniProt Gene Name
UniProt Entry Name
MAL_HUMAN
NCBI Summary for MAL
The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012]
UniProt Comments for MAL
MAL: Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function. Belongs to the MAL family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q11.1

Cellular Component: apical plasma membrane; endoplasmic reticulum; endosome; extrinsic to membrane; integral to plasma membrane; lipid raft

Molecular Function: apoptotic protease activator activity; channel activity; lipid binding; protein binding; structural constituent of myelin sheath

Biological Process: apical protein localization; apoptosis; cell differentiation; central nervous system development; lipid raft polarization; myelination; transmembrane transport
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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