BC005860
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,916 Da
NCBI Official Full Name
Homo sapiens TAR (HIV-1) RNA binding protein 2, mRNA
NCBI Official Synonym Full Names
TAR (HIV-1) RNA binding protein 2
NCBI Protein Information
RISC-loading complex subunit TARBP2; TAR (HIV) RNA binding protein 2; TAR (HIV) RNA-binding protein 2; TAR (HIV) RNA-binding protein TRBP1; TAR RNA binding protein 2; TAR RNA-binding protein 2; trans-activation responsive RNA-binding protein; trans-activation-responsive RNA-binding protein
UniProt Protein Name
RISC-loading complex subunit TARBP2
UniProt Synonym Protein Names
TAR RNA-binding protein 2; Trans-activation-responsive RNA-binding protein
UniProt Entry Name
TRBP2_HUMAN
NCBI Summary for TARBP2
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq, Jul 2008]
UniProt Comments for TARBP2
TRBP: the HIV-1 TAR RNA binding protein (TRBP) is a double strand RNA binding protein (dsRBP) that is required for the recruitment of Ago2 to the small interfering RNA (siRNA) bound by Dicer. TRBP increases HIV-1 expression and replication by inhibiting the interferon-induced protein kinase PKR and by increasing translation of viral mRNA. Dicer, Ago2, and TRBP are the main components of the RNA-induced silencing complex (RISC).
Protein type: Translation; Motility/polarity/chemotaxis; RNA-binding; RNA processing
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: nucleoplasm; perinuclear region of cytoplasm; cytoplasm; cytosol; nucleus
Molecular Function: protein binding; protein homodimerization activity; miRNA binding; siRNA binding; double-stranded RNA binding
Biological Process: regulation of translation; regulation of transcription from RNA polymerase II promoter; positive regulation of viral genome replication; regulation of transcription, DNA-dependent; pre-microRNA processing; regulation of viral transcription; RNA interference, targeting of mRNA for destruction; miRNA-mediated gene silencing, miRNA loading onto RISC; negative regulation of protein kinase activity; gene expression; negative regulation of defense response to virus by host; RNA interference, production of siRNA
Product References and Citations for anti-TARBP2 antibody
(1) De Vito,C., Riggi,N., Cornaz,S., et al. A TARBP2-dependent miRNA expression profile underlies cancer stem cell properties and provides candidate therapeutic reagents in Ewing sarcoma. Cancer Cell 21 (6), 807-821 (2012).
Research Articles on TARBP2
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Products associated with anti-TARBP2 antibody
Pathways associated with anti-TARBP2 antibody
Diseases associated with anti-TARBP2 antibody
Organs/Tissues associated with anti-TARBP2 antibody
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