NP_001191627.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
tax1-binding protein 3 isoform 2
NCBI Official Synonym Full Names
Tax1 binding protein 3
NCBI Official Synonym Symbols
NCBI Protein Information
tax1-binding protein 3
UniProt Protein Name
Tax1-binding protein 3
UniProt Synonym Protein Names
Glutaminase-interacting protein 3; Tax interaction protein 1; TIP-1; Tax-interacting protein 1
UniProt Synonym Gene Names
UniProt Entry Name
TX1B3_HUMAN
NCBI Summary for TAX1BP3
This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways; for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression of this gene has been implicated in altered cancer cell adhesion, migration and metastasis. The encoded protein also modulates the localization and density of inwardly rectifying potassium channel 2.3 (Kir2.3). To date, this protein has been shown to play a role in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017]
UniProt Comments for TAX1BP3
TAX1BP3: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.
Protein type: Cell cycle regulation; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 17p13
Cellular Component: cytoplasm; plasma membrane; nucleus; actin cytoskeleton
Molecular Function: protein C-terminus binding; protein binding; beta-catenin binding
Biological Process: negative regulation of cell proliferation; Wnt receptor signaling pathway; negative regulation of Wnt receptor signaling pathway; Rho protein signal transduction
Research Articles on TAX1BP3
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Products associated with anti-TAX1BP3 antibody
Pathways associated with anti-TAX1BP3 antibody
Diseases associated with anti-TAX1BP3 antibody
Organs/Tissues associated with anti-TAX1BP3 antibody
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