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anti-TGFBR1 antibody :: Rabbit TGFBR1 Polyclonal Antibody

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Catalog # MBS2530290
Unit / Price
  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

TGFBR1, Polyclonal Antibody

Popular Item
Also Known As

TGFBR1 Polyclonal Antibody

Product Synonym Names
AAT5; ALK5; MSSE; SKR4; ALK-5; LDS1A; LDS2A; TGFR-1; ACVRLK4
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
426
OMIM
132800
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
2.6mg/mL (lot specific)
Immunogen
Synthetic peptide of human TGFBR1
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-TGFBR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TGFBR1 antibody
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene.
Applications Tested/Suitable for anti-TGFBR1 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-TGFBR1 antibody
IHC: 1:100-1:300

Immunohistochemistry (IHC) of anti-TGFBR1 antibody
Immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using TGFBR1 Polyclonal Antibody at dilution 1:70
anti-TGFBR1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for TGFBR1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,690 Da
NCBI Official Full Name
TGFBR1 protein
NCBI Official Synonym Full Names
transforming growth factor, beta receptor 1
NCBI Official Symbol
TGFBR1  [Similar Products]
NCBI Official Synonym Symbols
AAT5; ALK5; ESS1; LDS1; MSSE; SKR4; ALK-5; LDS1A; LDS2A; TGFR-1; ACVRLK4; tbetaR-I
  [Similar Products]
NCBI Protein Information
TGF-beta receptor type-1; activin A receptor type II-like kinase, 53kDa; activin A receptor type II-like protein kinase of 53kD; activin receptor-like kinase 5; serine/threonine-protein kinase receptor R4; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD); transforming growth factor-beta receptor type I
UniProt Protein Name
TGF-beta receptor type-1
UniProt Synonym Protein Names
Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ALK-5; ALK5; Serine/threonine-protein kinase receptor R4; SKR4; TGF-beta type I receptor; Transforming growth factor-beta receptor type I; TGF-beta receptor type I; TbetaR-I
Protein Family
UniProt Gene Name
TGFBR1  [Similar Products]
UniProt Synonym Gene Names
ALK5; SKR4; TGFR-1; ALK-5; ALK5; SKR4; TGF-beta receptor type I; TbetaR-I  [Similar Products]
UniProt Entry Name
TGFR1_HUMAN
NCBI Summary for TGFBR1
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
UniProt Comments for TGFBR1
TGFBR1: a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Found in all tissues; most abundant in placenta and least abundant in brain and heart.

Protein type: Protein kinase, TKL; EC 2.7.11.30; Receptor, misc.; Protein kinase, Ser/Thr (receptor); Kinase, protein; Membrane protein, integral; TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: tight junction; membrane; cell; plasma membrane; receptor complex; endosome

Molecular Function: metal ion binding; punt binding; protein kinase activity; transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; transforming growth factor beta receptor activity, type I; transforming growth factor beta binding; growth factor binding; receptor signaling protein activity; SMAD binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: blastocyst development; collagen fibril organization; activation of MAPKK activity; heart development; positive regulation of transcription, DNA-dependent; negative regulation of chondrocyte differentiation; activin receptor signaling pathway; cell motility involved in cell locomotion; protein amino acid phosphorylation; post-embryonic development; anterior/posterior pattern formation; extracellular structure organization and biogenesis; transforming growth factor beta receptor signaling pathway; germ cell migration; kidney development; cell cycle arrest; neuron fate commitment; embryonic cranial skeleton morphogenesis; parathyroid gland development; positive regulation of cell growth; endothelial cell activation; mesenchymal cell differentiation; regulation of gene expression; negative regulation of endothelial cell proliferation; endothelial cell migration; positive regulation of endothelial cell proliferation; lens development in camera-type eye; wound healing; regulation of protein ubiquitination; apoptosis; palate development; signal transduction; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; angiogenesis; skeletal development; positive regulation of filopodium formation; pharyngeal system development; thymus development; in utero embryonic development; male gonad development; peptidyl-threonine phosphorylation; positive regulation of cell motility; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; skeletal morphogenesis; regulation of protein binding; epithelial to mesenchymal transition; artery morphogenesis; negative regulation of transforming growth factor beta receptor signaling pathway

Disease: Multiple Self-healing Squamous Epithelioma, Susceptibility To
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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