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anti-TICAM2 antibody :: Rabbit TICAM2 Polyclonal Antibody

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Catalog # MBS5400155
Unit / Price
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  0.1 mg  /  $495 +1 FREE 8GB USB
anti-TICAM2 antibody
Product Name

TICAM2, Polyclonal Antibody

Full Product Name

TICAM2 Antibody FITC-Conjugated

Product Synonym Names
Putative NF-kappa-B-activating protein 502; TICAM2; TIR containing adapter molecule 2; TIR domain-containing adapter molecule 2; TIRAP3; TIRP; Toll-like receptor adaptor protein 3; Toll/interleukin-1 receptor domain-containing protein; TRAM; TRIF-related adapter molecule antibody
Matching Pairs
Antibody: TICAM2 (MBS5400155)
Positive Control: TICAM2 (MBS543348)
Antibody/Peptide Pairs
TICAM2 peptide (MBS544609) is used for blocking the activity of TICAM2 antibody (MBS5400155)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
608321
3D Structure
ModBase 3D Structure for Q86XR7
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
FITC-Conjugated
Concentration
0.50-0.75 ug/ul in antibody stabilization buffer (lot specific)
Immunogen
Synthetic peptide corresponding to unique amino acid sequences on TRIF-related adapter molecule.
Expression
Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1).
Molecular Function
phospholipid binding, signal transducer activity
Structure
Homodimer. Interacts with TLR4, TICAM1, IRF3 and IRF7 in response to LPS. Interacts with IL1R1, IL1RAP, IRAK2, IRAK3 and TRAF6. Interacts with protein kinase-inactive mutants of IRAK1 and IRAK4. Isoform 1 interacts with isoform 2; the interaction occurs i
Subcellular Location
Isoform 1 : Cytoplasm. Golgi apparatus. Cell membrane. Endoplasmic Reticulum. Early endosome membrane. Late endosome membrane, Isoform 2 : Endoplasmic Reticulum. Early endosome membrane. Late endosome membrane, Isoform 2 : Endoplasmic Reticulum. Early end
Preparation and Storage
-20 degree C for long term storage
Other Notes
Small volumes of anti-TICAM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TICAM2 antibody
FITC-Conjugated TRIF-related adapter molecule Antibody
Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.
Applications Tested/Suitable for anti-TICAM2 antibody
Dot Blot (DB), ELISA (EIA), Western Blot (WB)
Application Notes for anti-TICAM2 antibody
Dot Blot: 1:20,000
ELISA: 1:20,000
Western Blot: 1:500-1:750
NCBI/Uniprot data below describe general gene information for TICAM2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,173 Da
NCBI Official Full Name
TRIF-related adapter molecule
NCBI Official Synonym Full Names
toll like receptor adaptor molecule 2
NCBI Official Symbol
TICAM2  [Similar Products]
NCBI Official Synonym Symbols
TIRP; TRAM; TIRAP3; MyD88-4; TICAM-2
  [Similar Products]
NCBI Protein Information
TIR domain-containing adapter molecule 2
UniProt Protein Name
TIR domain-containing adapter molecule 2
UniProt Synonym Protein Names
Putative NF-kappa-B-activating protein 502; TRIF-related adapter molecule; Toll-like receptor adaptor protein 3; Toll/interleukin-1 receptor domain-containing protein; MyD88-4
UniProt Gene Name
TICAM2  [Similar Products]
UniProt Synonym Gene Names
TIRAP3; TIRP; TRAM; TICAM-2; MyD88-4  [Similar Products]
UniProt Entry Name
TCAM2_HUMAN
NCBI Summary for TICAM2
TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM, Apr 2004]
UniProt Comments for TICAM2
Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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