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anti-TIMP-2 antibody :: Rabbit TIMP-2 Polyclonal Antibody

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Catalog # MBS2536441
Unit / Price
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  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Product Name

TIMP-2, Polyclonal Antibody

Popular Item
Full Product Name

TIMP-2 Polyclonal Antibody

Product Synonym Names
TIMP2; Metalloproteinase inhibitor 2; CSC-21K; Tissue inhibitor of metalloproteinases 2; TIMP-2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
188825
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Concentration
1 mg/ml (lot specific)
Immunogen
Synthesized peptide derived from the Internal region of human TIMP-2.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-TIMP-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-TIMP-2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-TIMP-2 antibody
WB: 1:500-1:2000, IHC: 1:50-1:200, IF: 1:50-1:100, ELISA: 1:5000-1:20000

Western Blot (WB) of anti-TIMP-2 antibody
Western Blot analysis of various cells using TIMP-2 Polyclonal Antibody at dilution of 1:1000.
anti-TIMP-2 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-TIMP-2 antibody
Immunohistochemistry of paraffin-embedded Mouse kidney using TIMP-2 antibody at dilution of 1:200
anti-TIMP-2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for TIMP-2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 24
Observed MW: 30
NCBI Official Full Name
tissue inhibitor of metalloproteinase 2
NCBI Official Synonym Full Names
TIMP metallopeptidase inhibitor 2
NCBI Official Symbol
TIMP2  [Similar Products]
NCBI Official Synonym Symbols
DDC8; CSC-21K
  [Similar Products]
NCBI Protein Information
metalloproteinase inhibitor 2
UniProt Protein Name
Metalloproteinase inhibitor 2
UniProt Synonym Protein Names
CSC-21K; Tissue inhibitor of metalloproteinases 2; TIMP-2
UniProt Gene Name
TIMP2  [Similar Products]
UniProt Synonym Gene Names
TIMP-2  [Similar Products]
UniProt Entry Name
TIMP2_HUMAN
NCBI Summary for TIMP-2
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]
UniProt Comments for TIMP-2
TIMP2: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. Interacts (via the C-terminal) with MMP2 (via the C- terminal PEX domain); the interaction inhibits the MMP2 activity. Down-regulated by TGFB1. Belongs to the protease inhibitor I35 (TIMP) family.

Protein type: Secreted; Secreted, signal peptide; Cell development/differentiation; Inhibitor; Motility/polarity/chemotaxis; Extracellular matrix

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: basement membrane; cell soma; cell surface; extracellular region; extracellular space; growth cone; proteinaceous extracellular matrix

Molecular Function: enzyme activator activity; integrin binding; metal ion binding; metalloendopeptidase inhibitor activity; protease binding; protein binding

Biological Process: aging; central nervous system development; extracellular matrix disassembly; extracellular matrix organization and biogenesis; negative regulation of cell proliferation; negative regulation of membrane protein ectodomain proteolysis; negative regulation of metalloenzyme activity; negative regulation of mitotic cell cycle; negative regulation of Ras protein signal transduction; positive regulation of adenylate cyclase activity; positive regulation of MAPKKK cascade; positive regulation of neuron differentiation; regulation of Rap protein signal transduction; response to cytokine stimulus; response to drug; response to hormone stimulus
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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