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anti-TOR1A antibody :: Rabbit TOR1A Polyclonal Antibody

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Catalog # MBS2526869
Unit / Price
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  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Product Name

TOR1A, Polyclonal Antibody

Popular Item
Full Product Name

TOR1A Antibody

Product Synonym Names
DQ2; DYT1; TorsinA
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
128100
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
1mg/mL (lot specific)
Immunogen
Recombinant protein of human TOR1A
Observed Molecular Weight: 38kDa
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-19482 / sc-19483 / sc-33606
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-TOR1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TOR1A antibody
The neurological condition Dystonia is associated with sustained muscle contractions and abnormal posturing (1). TorsinA, torsinB, torp2A and torp3A belong to the family of ATPases associated with cellular activites (AAA+) and mutations in torsinA cause early onset dystonia (2). TorsinA has been shown to suppress intracellular protein aggregation in C. elegans and possesses chaperon activity. Interestingly, torsinA is highly expressed in dopaminergic neurons and associates with alpha-synuclein in Lewy bodies, which pathologically characterize Parkinson's Disease (3-5).
Applications Tested/Suitable for anti-TOR1A antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-TOR1A antibody
WB (1:500-1:2000); IHC (1:50-1:200); IF (1:50-1:200)

Western Blot (WB) of anti-TOR1A antibody
Western blot analysis of extracts of various cell lines, using TOR1A antibody.
anti-TOR1A antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-TOR1A antibody
Immunohistochemistry of paraffin-embedded human normal breast using TOR1A antibody at dilution of 1:200(400x lens)
anti-TOR1A antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-TOR1A antibody
Immunohistochmistry of paraffin-embedded rat liver using TOR1A antibody at dilution of 1:200(400x lens)
anti-TOR1A antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for TOR1A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,135 Da
NCBI Official Full Name
torsin-1A
NCBI Official Synonym Full Names
torsin family 1, member A (torsin A)
NCBI Official Symbol
TOR1A  [Similar Products]
NCBI Official Synonym Symbols
DQ2; DYT1
  [Similar Products]
NCBI Protein Information
torsin-1A; dystonia 1 protein; dystonia 1, torsion (autosomal dominant; torsin A); torsin ATPase 1; torsin ATPase-1A; torsin family 1 member A
UniProt Protein Name
Torsin-1A
UniProt Synonym Protein Names
Dystonia 1 protein; Torsin ATPase-1A (EC:3.6.4.-); Torsin family 1 member A
Protein Family
UniProt Gene Name
TOR1A  [Similar Products]
UniProt Synonym Gene Names
DQ2; DYT1; TA; TORA  [Similar Products]
UniProt Entry Name
TOR1A_HUMAN
NCBI Summary for TOR1A
The protein encoded by this gene is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Mutations in this gene result in the autosomal dominant disorder, torsion dystonia 1. [provided by RefSeq, Jul 2008]
UniProt Comments for TOR1A
TOR1A: May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and nesprin-3/C14orf49, leaving nuclear pores and SUN1 unchanged. May form homohexamers. Interacts with TOR1AIP1 and TOR1AIP2. Interacts with KLHL14, preferentially when ATP-free. Widely expressed. Highest levels in kidney and liver. Not detected in spleen. In the brain, high levels found in the dopaminergic neurons of the substantia nigra pars compacta, as well as in the neocortex, hippocampus and cerebellum. Also high expression in the spinal cord. Belongs to the clpA/clpB family. Torsin subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: synaptic vesicle; nuclear membrane; transport vesicle; cytoskeleton; growth cone; cytoplasmic vesicle membrane; intracellular membrane-bound organelle; membrane; endoplasmic reticulum lumen; nuclear envelope; cell junction; secretory granule

Molecular Function: protein binding; kinesin binding; ATPase activity; unfolded protein binding; cytoskeletal protein binding; misfolded protein binding; ATP binding

Biological Process: protein deneddylation; chaperone cofactor-dependent protein folding; organelle organization and biogenesis; regulation of dopamine uptake; synaptic vesicle transport; intermediate filament cytoskeleton organization and biogenesis; response to oxidative stress; cell adhesion; nuclear membrane organization and biogenesis; neurite development; protein homooligomerization

Disease: Dystonia 1, Torsion, Autosomal Dominant
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-TOR1A antibody
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