P07951.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed MW: 36kDa Calculated MW: 28kDa/32kDa
NCBI Official Full Name
Tropomyosin beta chain
NCBI Official Synonym Full Names
tropomyosin 2 (beta)
NCBI Official Synonym Symbols
DA1; DA2B; NEM4; TMSB; AMCD1; HEL-S-273 [Similar Products]
NCBI Protein Information
tropomyosin beta chain; nemaline myopathy type 4; epididymis secretory protein Li 273
UniProt Protein Name
Tropomyosin beta chain
UniProt Synonym Protein Names
Beta-tropomyosin; Tropomyosin-2
UniProt Synonym Gene Names
UniProt Entry Name
TPM2_HUMAN
NCBI Summary for TPM2
This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
UniProt Comments for TPM2
TPM2: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. Defects in TPM2 are the cause of nemaline myopathy type 4 (NEM4). A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-or rod-like structures in muscle fibers on histologic examination. Nemaline myopathy type 4 presents from infancy to childhood with hypotonia and moderate-to-severe proximal weakness with minimal or no progression. Major motor milestones are delayed but independent ambulation is usually achieved, although a wheelchair may be needed in later life. Defects in TPM2 are the cause of distal arthrogryposis type 1A (DA1A). A form of distal arthrogryposis, a disease characterized by congenital joint flexures or contractures that mainly involve the distal parts of the limbs, and affect two or more different body areas in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 1 is characterized largely by camptodactyly and clubfoot. Hypoplasia and/or absence of some interphalangeal creases is common. The shoulders and hips are less frequently affected. Belongs to the tropomyosin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 9p13
Cellular Component: cytosol; muscle thin filament tropomyosin
Molecular Function: structural constituent of muscle; actin binding
Biological Process: regulation of ATPase activity; muscle contraction; muscle filament sliding
Disease: Nemaline Myopathy 4; Arthrogryposis, Distal, Type 1a; Myopathy, Congenital, With Fiber-type Disproportion; Arthrogryposis, Distal, Type 2b
Research Articles on TPM2
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Products associated with anti-TPM2 antibody
Pathways associated with anti-TPM2 antibody
Diseases associated with anti-TPM2 antibody
Organs/Tissues associated with anti-TPM2 antibody
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