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anti-TRAF4 antibody :: Rabbit TRAF4 Polyclonal Antibody

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Catalog # MBS7605152 (SPECIAL PROMOTIONAL PRICING for a limited time)
Unit / Price
  0.1 mg  /  $180 +1 FREE 8GB USB
anti-TRAF4 antibody
Product Name

TRAF4, Polyclonal Antibody

Also Known As

TRAF4 Rabbit Polyclonal

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
470
OMIM
602464
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Form/Format
Liquid
Immunogen
TNF receptor-associated factor 4
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-TRAF4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-TRAF4 antibody
ELISA (EIA), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for TRAF4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,841 Da
NCBI Official Full Name
TNF receptor-associated factor 4
NCBI Official Synonym Full Names
TNF receptor associated factor 4
NCBI Official Symbol
TRAF4  [Similar Products]
NCBI Official Synonym Symbols
CART1; MLN62; RNF83
  [Similar Products]
NCBI Protein Information
TNF receptor-associated factor 4
UniProt Protein Name
TNF receptor-associated factor 4
UniProt Synonym Protein Names
Cysteine-rich domain associated with RING and Traf domains protein 1; Metastatic lymph node gene 62 protein; MLN 62; RING finger protein 83
UniProt Gene Name
TRAF4  [Similar Products]
UniProt Synonym Gene Names
CART1; MLN62; RNF83; MLN 62  [Similar Products]
UniProt Entry Name
TRAF4_HUMAN
NCBI Summary for TRAF4
This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for TRAF4
TRAF4: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract. Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Belongs to the TNF receptor-associated factor family. B subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; DNA-binding

Chromosomal Location of Human Ortholog: 17q11-q12

Cellular Component: cytoplasm; cytoskeleton; nucleus; perinuclear region of cytoplasm; plasma membrane; tight junction

Molecular Function: DNA binding; protein binding; protein kinase binding; thioesterase binding; tumor necrosis factor receptor binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; WW domain binding; zinc ion binding

Biological Process: activation of NF-kappaB-inducing kinase; apoptosis; positive regulation of JNK cascade; positive regulation of protein kinase activity; protein ubiquitination; regulation of apoptosis; respiratory gaseous exchange; respiratory tube development; signal transduction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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