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anti-TSG101 antibody :: Rabbit TSG101 Polyclonal Antibody

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Catalog # MBS7605273 (SPECIAL PROMOTIONAL PRICING for a limited time)
Unit / Price
  0.1 mg  /  $180 +1 FREE 8GB USB
Product Name

TSG101, Polyclonal Antibody

Popular Item
Also Known As

TSG101 Rabbit Polyclonal

Product Synonym Names
ESCRT I complex subunit TSG101, TSG10, TSG101, tumor susceptibility gene 101, VPS23
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS7605273 Technical Datasheet
Immunogen Sequence Length
390
OMIM
601387
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse ,Rat; other species are not tested.
Specificity
Please decide the specificity by homology
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Form/Format
Liquid
Immunogen
Tumor susceptibility gene 101
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.3
Calculated MW
44 kDa
Preparation and Storage
Store at -20°C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-TSG101 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TSG101 antibody
The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression .
Applications Tested/Suitable for anti-TSG101 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-TSG101 antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:100

Immunohistochemistry of anti-TSG101 antibody
Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using MBS7605273 ( TSG101 Antibody)at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
anti-TSG101 antibody Immunohistochemistry (IHC) image
HeLa cells were subjected to SDS PAGE followed by western blot with MBS7605273 (TSG101 antibody) at dilution of 1:1000
anti-TSG101 antibody SDS PAGE  image
NCBI/Uniprot data below describe general gene information for TSG101. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
tumor susceptibility gene 101 protein
NCBI Official Synonym Full Names
tumor susceptibility 101
NCBI Official Symbol
TSG101  [Similar Products]
NCBI Official Synonym Symbols
TSG10; VPS23
  [Similar Products]
NCBI Protein Information
tumor susceptibility gene 101 protein
UniProt Protein Name
Tumor susceptibility gene 101 protein
UniProt Synonym Protein Names
ESCRT-I complex subunit TSG101
UniProt Gene Name
TSG101  [Similar Products]
UniProt Entry Name
TS101_HUMAN
NCBI Summary for TSG101
The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]
UniProt Comments for TSG101
TSG101: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Cell cycle regulation

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: cytoplasm; early endosome; endosome; endosome membrane; late endosome; late endosome membrane; multivesicular body; nucleolus; plasma membrane

Molecular Function: calcium-dependent protein binding; DNA binding; ligand-dependent nuclear receptor transcription coactivator activity; protein binding; protein homodimerization activity; transcription corepressor activity; ubiquitin binding; ubiquitin protein ligase binding; virion binding

Biological Process: autophagy; cell cycle arrest; cell division; endosome to lysosome transport; endosome transport; keratinocyte differentiation; negative regulation of cell proliferation; negative regulation of transcription, DNA-dependent; non-lytic virus budding; positive regulation of viral reproduction; protein monoubiquitination; protein transport; regulation of cell growth; regulation of MAP kinase activity; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; viral infectious cycle

Disease: Breast Cancer
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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