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anti-UBE2D2 antibody :: Rabbit UBE2D2 Polyclonal Antibody

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Catalog # MBS9203652
Unit / Price
  0.1 mL  /  $370 +1 FREE 8GB USB
Western Blot (WB)
Product Name

UBE2D2, Polyclonal Antibody

Popular Item
Full Product Name

UBE2D2 Antibody

Product Synonym Names
Ubiquitin-conjugating enzyme E2 D2; Ubiquitin carrier protein D2; Ubiquitin-conjugating enzyme E2(17)KB 2; Ubiquitin-conjugating enzyme E2-17 kDa 2; Ubiquitin-protein ligase D2; p53-regulated ubiquitin-conjugating enzyme 1; UBE2D2; PUBC1; UBC4; UBC5B; UBCH4; UBCH5B
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
81-140
OMIM
602962
3D Structure
ModBase 3D Structure for P62837
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, mouse, rat
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
Concentration
1mg/ml (lot specific)
Antigen Type
synthetic peptide
Antigen Source
KLH conjugated synthetic peptide derived from human UBE2D2
Preparation and Storage
Store at -20 degree C.Stable for 12 months from date of receipt
Other Notes
Small volumes of anti-UBE2D2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-UBE2D2 antibody
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.
Product Categories/Family for anti-UBE2D2 antibody
Applications Tested/Suitable for anti-UBE2D2 antibody
Western Blot (WB)
Application Notes for anti-UBE2D2 antibody
WB~~ 1:1000

Western Blot (WB) of anti-UBE2D2 antibody
All lanes : Anti-UBE2D2 Antibody at 1:1000 dilution
Lane 1: Hela whole cell lysates
Lane 2: HepG2 whole cell lysates

Lysates/proteins at 20 ug per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution

Predicted band size : 17 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.
anti-UBE2D2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for UBE2D2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17 KDa
NCBI Official Full Name
ubiquitin-conjugating enzyme E2 D2 isoform 1
NCBI Official Synonym Full Names
ubiquitin-conjugating enzyme E2D 2
NCBI Official Symbol
UBE2D2  [Similar Products]
NCBI Official Synonym Symbols
UBC4; PUBC1; UBCH4; UBC4/5; UBCH5B; E2(17)KB2
  [Similar Products]
NCBI Protein Information
ubiquitin-conjugating enzyme E2 D2
UniProt Protein Name
Ubiquitin-conjugating enzyme E2 D2
UniProt Synonym Protein Names
Ubiquitin carrier protein D2; Ubiquitin-conjugating enzyme E2(17)KB 2; Ubiquitin-conjugating enzyme E2-17 kDa 2; Ubiquitin-protein ligase D2; p53-regulated ubiquitin-conjugating enzyme 1
UniProt Gene Name
UBE2D2  [Similar Products]
UniProt Synonym Gene Names
PUBC1; UBC4; UBC5B; UBCH4; UBCH5B  [Similar Products]
UniProt Entry Name
UB2D2_HUMAN
NCBI Summary for UBE2D2
Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
UniProt Comments for UBE2D2
UBE2D2: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3. Belongs to the ubiquitin-conjugating enzyme family.

Protein type: Ubiquitin ligase; EC 6.3.2.19; Ligase; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 5q31.2

Cellular Component: nucleoplasm; protein complex; cytosol; ubiquitin ligase complex

Molecular Function: protein binding; ubiquitin-protein ligase activity; ATP binding; ligase activity

Biological Process: ubiquitin-dependent protein catabolic process; protein polyubiquitination; MyD88-independent toll-like receptor signaling pathway; toll-like receptor signaling pathway; protein modification process; innate immune response; protein ubiquitination; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway
Product References and Citations for anti-UBE2D2 antibody
Jensen J.P.,et al.J. Biol. Chem. 270:30408-30414(1995).
Rolfe M.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:3264-3268(1995).
Guinn B.-A.,et al.Biochem. Biophys. Res. Commun. 335:1293-1304(2005).
Yin Y.,et al.Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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