Q712K3.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Ubiquitin-conjugating enzyme E2 R2
NCBI Official Synonym Full Names
ubiquitin-conjugating enzyme E2R 2
NCBI Protein Information
ubiquitin-conjugating enzyme E2 R2; ubiquitin-protein ligase R2; ubiquitin carrier protein R2; ubiquitin-conjugating enzyme UBC3B; ubiquitin-conjugating enzyme E2-CDC34B
UniProt Protein Name
Ubiquitin-conjugating enzyme E2 R2
UniProt Synonym Protein Names
Ubiquitin carrier protein R2; Ubiquitin-conjugating enzyme E2-CDC34B; Ubiquitin-protein ligase R2
UniProt Synonym Gene Names
UniProt Entry Name
UB2R2_HUMAN
NCBI Summary for UBE2R2
Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008]
UniProt Comments for UBE2R2
UBC3B: an E2 ubiquitin conjugating enzyme similar to UBC3/CDC34. Phosphorylation of UBC3B by CK2 induces its interaction with beta-TrCP, regulating beta-TrCP substrate recognition and enhancing beta-catenin degradation.
Protein type: EC 6.3.2.19; Ubiquitin ligase; Ligase; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component: cytoplasm
Molecular Function: small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; ATP binding; ligase activity
Biological Process: protein monoubiquitination; proteasomal ubiquitin-dependent protein catabolic process
Research Articles on UBE2R2
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Products associated with anti-UBE2R2 antibody
Pathways associated with anti-UBE2R2 antibody
Organs/Tissues associated with anti-UBE2R2 antibody
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