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anti-UNC93B antibody :: Rabbit UNC93B / UNC93B1 Polyclonal Antibody

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Catalog # MBS242310
Unit / Price
  0.05 mg  /  $530 +1 FREE 8GB USB
Product Name

UNC93B / UNC93B1, Polyclonal Antibody

Also Known As

Rabbit Polyclonal to Human UNC93B / UNC93B1

Product Synonym Names
Anti-UNC93B / UNC93B1 Antibody (N-Terminus) IHC-plus; UNC93B1; IIAE1; Unc-93 homolog B1 (C. elegans); UNC93; UNC93B; Protein unc-93 homolog B1; Unc93 homolog B; HUNC93B1; Unc-93 related protein; Unc-93B1; Unc93 (C. elegans) homolog B1; Unc93 homolog B1; Human UNC93B; UNC93B1
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
597
OMIM
gene 610551
3D Structure
ModBase 3D Structure for Q9H1C4
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.02% sodium azide.
Concentration
1 mg/ml (lot specific)
Target Species
Human
Immunogen Description
19 amino acid peptide from near the amino terminus of human Unc93b.
Immunogen
UNC93B / UNC93B1 antibody was raised against 19 amino acid peptide from near the amino terminus of human Unc93b.
Antigen Modification
N-Terminus
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Other Notes
Small volumes of anti-UNC93B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-UNC93B antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-UNC93B antibody
ELISA, IHC-P (5 ug/ml), WB (0.5 - 1 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-UNC93B antibody
Anti-UNC93B1 / UNC93B antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-UNC93B antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-UNC93B antibody
Immunofluorescence of Unc93b in Human Heart cells with Unc93b antibody at 20 ug/ml.
anti-UNC93B antibody Immunofluorescence (IF) image
Western Blot (WB) of anti-UNC93B antibody
Western blot of Unc93b in human heart tissue lysate with Unc93b antibody at (A) 0.5 and (B) 1 ug/ml.
anti-UNC93B antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for UNC93B. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
66,631 Da
NCBI Official Full Name
protein unc-93 homolog B1
NCBI Official Synonym Full Names
unc-93 homolog B1 (C. elegans)
NCBI Official Symbol
UNC93B1  [Similar Products]
NCBI Official Synonym Symbols
IIAE1; UNC93; UNC93B; Unc-93B1
  [Similar Products]
NCBI Protein Information
protein unc-93 homolog B1; unc93 homolog B1; unc-93 related protein
UniProt Protein Name
Protein unc-93 homolog B1
UniProt Gene Name
UNC93B1  [Similar Products]
UniProt Synonym Gene Names
UNC93; UNC93B; Unc-93B1; hUNC93B1  [Similar Products]
UniProt Entry Name
UN93B_HUMAN
NCBI Summary for UNC93B
This gene encodes a protein that is involved in innate and adaptive immune response by regulating toll-like receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis. [provided by RefSeq, Feb 2014]
UniProt Comments for UNC93B
UNC93B1: Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B- cells removal. Defects in UNC93B1 are associated with herpes simplex encephalitis type 1 (HSE1). HSE is a rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. Mutations in UNC93B1 resulting in autosomal recessive UNC93B1 deficieny predispose otherwise healthy individuals to isolated herpes simplex encephalitis due to impaired IFNs production. UNC93B1 deficieny, however, does not compromise immunity to most pathogens, unlike most known primary immunodeficiencies. Belongs to the unc-93 family.

Protein type: Membrane protein, multi-pass; Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: Golgi membrane; endoplasmic reticulum membrane; lysosome; endoplasmic reticulum; integral to membrane; endosome

Biological Process: intracellular protein transport; toll-like receptor signaling pathway; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class II; toll-like receptor 3 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor 7 signaling pathway; defense response to virus

Disease: Herpes Simplex Encephalitis, Susceptibility To, 1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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