NP_001245136.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 95 kDa Predicted: 99 kDa
NCBI Official Full Name
proto-oncogene vav isoform 3
NCBI Official Synonym Full Names
vav guanine nucleotide exchange factor 1
NCBI Official Synonym Symbols
NCBI Protein Information
proto-oncogene vav
UniProt Protein Name
Proto-oncogene vav
UniProt Synonym Gene Names
NCBI Summary for VAV1
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
UniProt Comments for VAV1
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
Research Articles on VAV1
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Products associated with anti-VAV1 antibody
Pathways associated with anti-VAV1 antibody
Diseases associated with anti-VAV1 antibody
Organs/Tissues associated with anti-VAV1 antibody
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