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anti-VPRBP antibody :: Rabbit Vpr (HIV-1) binding protein Polyclonal Antibody

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Catalog # MBS713791
Unit / Price
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  0.05 mL  /  $230 +1 FREE 8GB USB
  0.15 mL  /  $500 +1 FREE 8GB USB
anti-VPRBP antibody
Product Name

Vpr (HIV-1) binding protein (VPRBP), Polyclonal Antibody

Full Product Name

Rabbit anti-human Vpr (HIV-1) binding protein polyclonal Antibody

Product Synonym Names
Vpr (HIV-1) binding protein; VPRBP; DCAF1; KIAA0800; MGC102804
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Immunogen
Human VPRBP
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-82419 / sc-98531
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-VPRBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-VPRBP antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for VPRBP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
118,235 Da[Similar Products]
NCBI Official Full Name
Vpr (HIV-1) binding protein, isoform CRA_d
NCBI Official Synonym Full Names
Vpr (HIV-1) binding protein
NCBI Official Symbol
VPRBP  [Similar Products]
NCBI Official Synonym Symbols
DCAF1
  [Similar Products]
NCBI Protein Information
protein VPRBP; Vpr-binding protein; vpr-interacting protein; HIV-1 Vpr-binding protein; DDB1 and CUL4 associated factor 1; DDB1- and CUL4-associated factor 1; serine/threonine-protein kinase VPRBP
UniProt Protein Name
Protein VPRBP
UniProt Synonym Protein Names
DDB1- and CUL4-associated factor 1; HIV-1 Vpr-binding protein; VprBP; Serine/threonine-protein kinase VPRBP (EC:2.7.11.1); Vpr-interacting protein
Protein Family
UniProt Gene Name
VPRBP  [Similar Products]
UniProt Synonym Gene Names
DCAF1; KIAA0800; RIP; VprBP  [Similar Products]
UniProt Entry Name
VPRBP_HUMAN
UniProt Comments for VPRBP
VPRBP: Component of the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex, VprBP/DCAF1 may function as the substrate recognition module within this complex. For example, VprBP/DCAF1 targets NF2 to the E3 ubiquitin-ligase complex for ubiquitination and subsequent proteasome-dependent degradation. In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1 function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1 function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage. Associated with chromatin in a DDB1-independent and cell cycle-dependent manner, VprBP/DCAF1 is recruited to chromatin as DNA is being replicated and is released from chromatin before mitosis. Belongs to the VPRBP/DCAF1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; EC 2.7.11.1

Chromosomal Location of Human Ortholog: 3p21.2

Cellular Component: signalosome; cytoplasm; nucleolus; nucleus

Molecular Function: protein binding; ATP binding

Biological Process: V(D)J recombination; transcription, DNA-dependent; viral reproduction; B cell differentiation; cell competition in a multicellular organism; protein ubiquitination; negative regulation of transcription from RNA polymerase II promoter
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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