Q96QK1.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Vacuolar protein sorting-associated protein 35
NCBI Official Synonym Full Names
vacuolar protein sorting 35 homolog (S. cerevisiae)
NCBI Official Synonym Symbols
NCBI Protein Information
vacuolar protein sorting-associated protein 35; hVPS35; maternal-embryonic 3
UniProt Protein Name
Vacuolar protein sorting-associated protein 35
UniProt Synonym Protein Names
Maternal-embryonic 3; Vesicle protein sorting 35
UniProt Synonym Gene Names
UniProt Entry Name
VPS35_HUMAN
NCBI Summary for VPS35
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008]
UniProt Comments for VPS35
VPS35: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Defects in VPS35 are the cause of Parkinson disease type 17 (PARK17). PARK17 is an autosomal dominant, adult- onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. Belongs to the VPS35 family.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 16q12
Cellular Component: retromer complex; lysosomal membrane; early endosome; late endosome; cytosol; endosome
Molecular Function: protein binding; protein transporter activity
Biological Process: intracellular protein transport; transcytosis; retrograde transport, endosome to Golgi
Disease: Parkinson Disease 17
Research Articles on VPS35
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Pathways associated with anti-VPS35 antibody
Diseases associated with anti-VPS35 antibody
Organs/Tissues associated with anti-VPS35 antibody
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