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anti-ZBP1 antibody :: Rabbit ZBP1 Polyclonal Antibody

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Catalog # MBS150830
Unit / Price
  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

ZBP1, Polyclonal Antibody

Popular Item
Also Known As

ZBP1 Antibody

Product Synonym Names
ZBP1; DAI; DLM1; DLM-1; C20orf183; Z-DNA-binding protein 1; Tumor stroma and activated macrophage protein DLM-1; Z-DNA binding protein 1
Antibody/Peptide Pairs
ZBP1 peptide (MBS153012) is used for blocking the activity of ZBP1 antibody (MBS150830)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
406
OMIM
606750
3D Structure
ModBase 3D Structure for Q9H171
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
ZBP1 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (lot specific)
Conjugate
Unconjugated
Immunogen
ZBP1 antibody was raised against a 18 amino acid synthetic peptide from near the carboxy terminus of human ZBP1.
Buffer
ZBP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
ZBP1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-ZBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ZBP1 antibody
ZBP1 Antibody: Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Zalpha domain which binds specifically to left-handed Z-DNA and Z-RNA. ZBP1 was initially identified as a novel gene that was up-regulated in activated macrophages in mice bearing ascites tumors, suggesting that is may play a role in processes such as host response in neoplasia. More recent reports indicate that the cytosolic ZBP1 has can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (also known as NAK). Multiple isoforms of ZBP1 are known to exist.
Applications Tested/Suitable for anti-ZBP1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-ZBP1 antibody
ZBP1 antibody can be used for the detection of ZBP1 by Western blot at 0.5 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-ZBP1 antibody
Western blot analysis of ZBP1 in mouse small intestine tissue lysate with ZBP1 antibody at (A) 0.5, (B) 1 and (C) 2 μg/mL.
anti-ZBP1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-ZBP1 antibody
Immunohistochemistry of ZBP1 in human small intestine tissue with ZBP1 antibody at 2.5 μg/mL.
anti-ZBP1 antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-ZBP1 antibody
Immunofluorescence of ZBP1 in Human Small Intestine tissue with ZBP1 antibody at 20 μgg/mL.
anti-ZBP1 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for ZBP1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,220 Da
NCBI Official Full Name
Z-DNA binding protein 1, isoform CRA_b
NCBI Official Synonym Full Names
Z-DNA binding protein 1
NCBI Official Symbol
NCBI Official Synonym Symbols
DAI; DLM1; DLM-1; C20orf183
  [Similar Products]
NCBI Protein Information
Z-DNA-binding protein 1; DNA-dependent activator of IRFs; DNA-dependent activator of IFN-regulatory factors; tumor stroma and activated macrophage protein DLM-1; DNA-dependent activator of interferon regulatory factors
UniProt Protein Name
Z-DNA-binding protein 1
UniProt Synonym Protein Names
Tumor stroma and activated macrophage protein DLM-1
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
C20orf183; DLM1  [Similar Products]
UniProt Entry Name
ZBP1_HUMAN
NCBI Summary for ZBP1
This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
UniProt Comments for ZBP1
ZBP1: Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; DNA-binding

Chromosomal Location of Human Ortholog: 20q13.31

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: double-stranded RNA adenosine deaminase activity; protein binding; DNA binding; left-handed Z-DNA binding; RNA binding

Biological Process: metabolic process; positive regulation of interferon type I production; innate immune response
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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