NP_001229813.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
zinc finger and BTB domain-containing protein 17 isoform 1
NCBI Official Synonym Full Names
zinc finger and BTB domain containing 17
NCBI Protein Information
zinc finger and BTB domain-containing protein 17
UniProt Protein Name
Zinc finger and BTB domain-containing protein 17
UniProt Synonym Protein Names
Myc-interacting zinc finger protein 1; Miz-1; Zinc finger protein 151; Zinc finger protein 60
UniProt Synonym Gene Names
UniProt Entry Name
ZBT17_HUMAN
NCBI Summary for ZBTB17
This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. [provided by RefSeq, Jul 2008]
UniProt Comments for ZBTB17
ZBTB17: May function as a housekeeping DNA-binding protein that regulates the expression of specific genes. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Also has potent growth arrest activity, probably through inhibition of cell cycle progression. Required for early embryonic development during gastrulation. Belongs to the krueppel C2H2-type zinc-finger protein family. Binds to the C-terminal helix-loop-helix motif of MYC which inhibits ZBTB17 transactivation and growth arrest activities and renders it insoluble in the nucleus. Also interacts with HCFC1, MAGEA4 and TMPRSS11A. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 1p36.13
Cellular Component: nucleoplasm
Molecular Function: protein binding; DNA binding; metal ion binding; transcription factor activity
Biological Process: cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; transcription, DNA-dependent; unfolded protein response; positive regulation of transcription, DNA-dependent; ectoderm development; gastrulation with mouth forming second; negative regulation of cell cycle
Research Articles on ZBTB17
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Products associated with anti-ZBTB17 antibody
Pathways associated with anti-ZBTB17 antibody
Diseases associated with anti-ZBTB17 antibody
Organs/Tissues associated with anti-ZBTB17 antibody
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