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anti-ZFYVE27 antibody :: Rabbit ZFYVE27 Polyclonal Antibody

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Catalog # MBS9214784
Unit / Price
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  0.08 mL  /  $165 +1 FREE 8GB USB
  0.4 mL  /  $370 +1 FREE 8GB USB
Western Blot (WB)
Product Name

ZFYVE27, Polyclonal Antibody

Popular Item
Full Product Name

ZFYVE27 Antibody (N-term)

Product Synonym Names
Protrudin; Zinc finger FYVE domain-containing protein 27; ZFYVE27
Antibody/Peptide Pairs
ZFYVE27 peptide (MBS9222301) is used for blocking the activity of ZFYVE27 antibody (MBS9214784)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
28-56
OMIM
610243
3D Structure
ModBase 3D Structure for Q5T4F4
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human (Predicted Reactivity: Mouse, Rat)
Specificity
This ZFYVE27 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-56 amino acids from the N-terminal region of human ZFYVE27.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Primary Accession
Q5T4F4
Other Accession
Q6P7B7, Q3TXX3, NP_001002261.1, NP_001002262.1
Antigen Source
HUMAN
Function
Functions as an upstream inhibitor of RAB11, regulating directional protein transport to the forming neurites. Involved in nerve growth factor-induced neurite formation. May have a more general role in cell projections formation.
Cellular Location
Recycling endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, growth cone membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein Note=Localizes at both dendrites and axons.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-ZFYVE27 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ZFYVE27 antibody
This gene encodes a protein with several transmembrane
domains, a Rab11-binding domain and a lipid-binding FYVE finger
domain. The encoded protein appears to promote neurite formation. A
mutation in this gene has been reported to be associated with
hereditary spastic paraplegia, however the pathogenicity of the
mutation, which may simply represent a polymorphism, is unclear.
Product Categories/Family for anti-ZFYVE27 antibody
Applications Tested/Suitable for anti-ZFYVE27 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ZFYVE27 antibody
WB~~1:1000

Western Blot (WB) of anti-ZFYVE27 antibody
ZFYVE27 Antibody (N-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the ZFYVE27 antibody detected the ZFYVE27 protein (arrow).
anti-ZFYVE27 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ZFYVE27. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45843
NCBI Official Full Name
protrudin isoform a
NCBI Official Synonym Full Names
zinc finger, FYVE domain containing 27
NCBI Official Symbol
ZFYVE27  [Similar Products]
NCBI Official Synonym Symbols
SPG33; PROTRUDIN
  [Similar Products]
NCBI Protein Information
protrudin
UniProt Protein Name
Protrudin
UniProt Synonym Protein Names
Zinc finger FYVE domain-containing protein 27
Protein Family
UniProt Gene Name
ZFYVE27  [Similar Products]
UniProt Entry Name
ZFY27_HUMAN
NCBI Summary for ZFYVE27
This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear. [provided by RefSeq, Mar 2010]
UniProt Comments for ZFYVE27
ZFYVE27: Functions as an upstream inhibitor of RAB11, regulating directional protein transport to the forming neurites. Involved in nerve growth factor-induced neurite formation. May have a more general role in cell projections formation. Defects in ZFYVE27 are the cause of spastic paraplegia autosomal dominant type 33 (SPG33). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. According to PubMed:18606302, the properties of the variant Val-191 and its frequency in some populations raise doubts on the implication of that gene in the disease. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Cytoskeletal

Chromosomal Location of Human Ortholog: 10q24.2

Cellular Component: endoplasmic reticulum membrane; recycling endosome membrane; axon; endoplasmic reticulum; dendrite; integral to membrane

Molecular Function: protein binding; metal ion binding

Biological Process: nerve growth factor receptor signaling pathway; neurite development

Disease: Spastic Paraplegia 33, Autosomal Dominant
Product References and Citations for anti-ZFYVE27 antibody
Saita, S., et al. J. Biol. Chem. 284(20):13766-13777(2009)
Martignoni, M., et al. Am. J. Hum. Genet. 83(1):127-128(2008)
Shirane, M., et al. Science 314(5800):818-821(2006)
Mannan, A.U., et al. Am. J. Hum. Genet. 79(2):351-357(2006)
Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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Diseases associated with anti-ZFYVE27 antibody
Organs/Tissues associated with anti-ZFYVE27 antibody
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