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anti-ZC3HC1 antibody :: Rabbit zinc finger, C3HC-type containing 1 Polyclonal Antibody

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Catalog # MBS711057
Unit / Price
  0.05 mL  /  $230 +1 FREE 8GB USB
  0.15 mL  /  $500 +1 FREE 8GB USB
anti-ZC3HC1 antibody
Product Name

zinc finger, C3HC-type containing 1 (ZC3HC1), Polyclonal Antibody

Also Known As

Rabbit anti-human zinc finger, C3HC-type containing 1 polyclonal Antibody

Product Synonym Names
zinc finger; C3HC-type containing 1; ZC3HC1; 1110054L24Rik; HSPC216; NIPA
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
502
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Immunogen
Human ZC3HC1
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-48603 / sc-48605
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-ZC3HC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ZC3HC1 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for ZC3HC1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,771 Da[Similar Products]
NCBI Official Full Name
Zinc finger, C3HC-type containing 1
NCBI Official Synonym Full Names
zinc finger, C3HC-type containing 1
NCBI Official Symbol
ZC3HC1  [Similar Products]
NCBI Official Synonym Symbols
NIPA; HSPC216
  [Similar Products]
NCBI Protein Information
nuclear-interacting partner of ALK; hematopoietic stem/progenitor cell protein 216; nuclear interacting partner of anaplastic lymphoma kinase (ALK)
UniProt Protein Name
Nuclear-interacting partner of ALK
UniProt Synonym Protein Names
Nuclear-interacting partner of anaplastic lymphoma kinase; hNIPA; Zinc finger C3HC-type protein 1
Protein Family
UniProt Gene Name
ZC3HC1  [Similar Products]
UniProt Synonym Gene Names
NIPA; hNIPA  [Similar Products]
UniProt Entry Name
NIPA_HUMAN
NCBI Summary for ZC3HC1
This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis. [provided by RefSeq, Aug 2013]
UniProt Comments for ZC3HC1
NIPA: a nuclear protein that interacts with anaplastic lymphoma kinase (ALK). An essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1. Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting cyclin B1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of cyclin B1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. Interacts with the NPM-ALK fusion protein in a tyrosine phosphorylation-dependent manner. Three splice-variant isoforms have been described.

Protein type: Cell cycle regulation; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 7q32.2

Cellular Component: nuclear membrane; nucleus

Molecular Function: protein binding; zinc ion binding; protein kinase binding

Biological Process: mitosis; cell division; protein ubiquitination
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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