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anti-Slc39a14 antibody :: Rabbit ZIP14 Polyclonal Antibody

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Catalog # MBS151580
Unit / Price
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  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

ZIP14 (Slc39a14), Polyclonal Antibody

Popular Item
Full Product Name

ZIP14 Antibody

Product Synonym Names
ZIP14; NET34; ZIP14; cig19; LZT-Hs4; KIAA0062; Zinc transporter ZIP14; LIV-1 subfamily of ZIP zinc transporter 4; solute carrier family 39 (zinc transporter), member 14
Antibody/Peptide Pairs
ZIP14 peptide (MBS153167) is used for blocking the activity of ZIP14 antibody (MBS151580)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
608736
3D Structure
ModBase 3D Structure for Q15043
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
At least three isoforms of ZIP14 are known to exist; this antibody will detect both isoforms. ZIP14 antibody is predicted to not cross-react with other ZIP family members.
Purity/Purification
ZIP14 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (lot specific)
Conjugate
Unconjugated
Immunogen
ZIP14 antibody was raised against a 16 amino acid synthetic peptide near the center of human ZIP14.
Immunogen is located withing amino acids 230-280 of ZIP14
Buffer
ZIP14 Antibody is supplied in PBS containing 0.02% sodium azide.
Predicted Molecular Weight
54 kDa
Observed Molecular Weight
52 kDa
Positive Control
MBS151674-Human Spleen Tissue Lysate.
Homology
Predicted species reactivity bases on immunogen sequence: Bovine: (94%).
Preparation and Storage
ZIP14 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-Slc39a14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Slc39a14 antibody
ZIP14 Antibody: The zinc transporter ZIP14, also known as SLC39A14, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP14 is a glycosylated multipass plasma membrane protein that belongs to the ZIP transporter subfamily LIV-1. ZIP14 has been shown to contribute to the hypozincemia of inflammation and infection and is regulated in the liver by IL-6. In addition to zinc, ZIP14 is also involved in the cellular uptake of non-transferrin-bound iron as well as iron bound to transferrin.
Applications Tested/Suitable for anti-Slc39a14 antibody
ELISA. IF, IHC-P, WB
Application Notes for anti-Slc39a14 antibody
ZIP14 antibody can be used for detection of ZIP14 by Western blot at 1 - 2 ug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 ug/mL. For immunofluorescence start at 20 ug/mL.

Optimal dilutions for each application to be determined by the researcher.

Western Blot (WB) of anti-Slc39a14 antibody
Western blot analysis of ZIP14 in human spleen tissue lysate with ZIP14 antibody at (A) 1 and (B) 2 μg/mL.
anti-Slc39a14 antibody Western Blot (WB) (WB) image
Immunofluorescence (IF) of anti-Slc39a14 antibody
Immunofluorescence of ZIP14 in Mouse Liver tissue with ZIP14 antibody at 20 μg/mL.
anti-Slc39a14 antibody Immunofluorescence (IF) image
Immunohistochemistry (IHC) of anti-Slc39a14 antibody
Immunohistochemistry of ZIP14 in mouse liver tissue with ZIP14 antibody at 2.5 μg/mL.
anti-Slc39a14 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for Slc39a14. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
zinc transporter ZIP14 isoform a
NCBI Official Synonym Full Names
solute carrier family 39 (zinc transporter), member 14
NCBI Official Symbol
SLC39A14  [Similar Products]
NCBI Official Synonym Symbols
NET34; ZIP14; cig19; LZT-Hs4
  [Similar Products]
NCBI Protein Information
zinc transporter ZIP14; ZIP-14; Zrt-, Irt-like protein 14; zrt- and Irt-like protein 14; solute carrier family 39 member 14; LIV-1 subfamily of ZIP zinc transporter 4; solute carrier family 39 (metal ion transporter), member 14
UniProt Protein Name
Zinc transporter ZIP14
UniProt Synonym Protein Names
LIV-1 subfamily of ZIP zinc transporter 4; LZT-Hs4; Solute carrier family 39 member 14; Zrt- and Irt-like protein 14; ZIP-14
Protein Family
UniProt Gene Name
SLC39A14  [Similar Products]
UniProt Synonym Gene Names
KIAA0062; ZIP14; LZT-Hs4; ZIP-14  [Similar Products]
UniProt Entry Name
S39AE_HUMAN
NCBI Summary for Slc39a14
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A14 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
UniProt Comments for Slc39a14
SLC39A14: May mediate cellular uptake of nontransferrin-bound iron. Broad-scope metal ion transporter with a preference for zinc uptake. Belongs to the ZIP transporter (TC 2.A.5) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, SLC family; Transporter

Chromosomal Location of Human Ortholog: 8p21.3

Cellular Component: Golgi apparatus; lamellipodium; integral to plasma membrane; endoplasmic reticulum; integral to membrane; plasma membrane

Molecular Function: zinc ion transmembrane transporter activity; ferrous iron transmembrane transporter activity

Biological Process: ferrous iron transport; cellular zinc ion homeostasis; transmembrane transport
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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