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anti-BICC1 antibody :: Rabbit BICC1 Polyclonal Antibody

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Catalog # MBS9204871
Unit / Price
  0.08 mL  /  $165 +1 FREE 8GB USB
  0.4 mL  /  $370 +1 FREE 8GB USB
Product Name

BICC1, Polyclonal Antibody

Popular Item
Also Known As

BICC1 Antibody (N-term)

Product Synonym Names
Protein bicaudal C homolog 1; Bic-C; BICC1
Antibody/Peptide Pairs
BICC1 peptide (MBS9226460) is used for blocking the activity of BICC1 antibody (MBS9204871)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
80-107
Immunogen Sequence Length
880
OMIM
601331
3D Structure
ModBase 3D Structure for Q9H694
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human (Predicted Reactivity: Xenopus, Mouse)
Specificity
This BICC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-107 amino acids from the N-terminal region of human BICC1.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Cellular Location
Cytoplasm
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-BICC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BICC1 antibody
BICC1 is an RNA-binding protein that is active in regulating gene expression by modulating protein translation during embryonic development. Mouse studies identified the corresponding protein to be under strict control during cell differentiation and to be a maternally provided gene product.
Function: Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.
Applications Tested/Suitable for anti-BICC1 antibody
Western Blot (WB), Immunohistochemistry Parfaffin(IHC-P)
Application Notes for anti-BICC1 antibody
WB~~1:1000
IHC-P ~~1:10~50

Western Blot (WB) of anti-BICC1 antibody
Western blot analysis of BICC1 Antibody (N-term) in HL-60 cell line lysates (35ug/lane). BICC1 (arrow) was detected using the purified Pab.
anti-BICC1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-BICC1 antibody
Formalin-fixed and paraffin-embedded human brain tissue reacted with BICC1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
anti-BICC1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for BICC1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
NCBI Official Full Name
protein bicaudal C homolog 1
NCBI Official Synonym Full Names
BicC family RNA binding protein 1
NCBI Official Symbol
BICC1  [Similar Products]
NCBI Official Synonym Symbols
BICC; CYSRD
  [Similar Products]
NCBI Protein Information
protein bicaudal C homolog 1
UniProt Protein Name
Protein bicaudal C homolog 1
Protein Family
UniProt Gene Name
BICC1  [Similar Products]
UniProt Synonym Gene Names
Bic-C  [Similar Products]
UniProt Entry Name
BICC1_HUMAN
NCBI Summary for BICC1
This gene encodes an RNA-binding protein that is active in regulating gene expression by modulating protein translation during embryonic development. Mouse studies identified the corresponding protein to be under strict control during cell differentiation and to be a maternally provided gene product. [provided by RefSeq, Apr 2009]
UniProt Comments for BICC1
BICC1: Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development. Defects in BICC1 are a cause of susceptibility to renal dysplasia, cystic (CYSRD). An anomaly of the kidney characterized by numerous renal cysts and apparent disorder of differentiation of the renal parenchyma. Kidney of affected individuals lack the normal renal bean shape, and the collection drainage system. The cystic, dysplastic kidney contains undifferentiated mesenchyme, cartilaginous tissue, and immature collecting ducts. Belongs to the BicC family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 10q21.1

Cellular Component: cytoplasm

Biological Process: multicellular organismal development

Disease: Renal Dysplasia, Cystic, Susceptibility To
Product References and Citations for anti-BICC1 antibody
Grupe,A., et.al., Am. J. Hum. Genet. 78 (1), 78-88 (2006)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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