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anti-ADAM22 antibody :: Rabbit anti-Human, Pig A Disintegrin And Metalloprotease 22 Polyclonal Antibody

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Catalog # MBS2032276 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
  0.01 mg  /  $110 +1 FREE 8GB USB
  0.02 mg  /  $130 +1 FREE 8GB USB
  0.05 mg  /  $175 +1 FREE 8GB USB
  0.1 mg  /  $225 +1 FREE 8GB USB
  0.2 mg  /  $340 +1 FREE 8GB USB
  1 mg  /  $800 +1 FREE 8GB USB
Product Name

A Disintegrin And Metalloprotease 22 (ADAM22), Polyclonal Antibody

Also Known As

A Disintegrin And Metalloprotease 22 (ADAM22) Polyclonal Antibody

Product Synonym Names
MDC2; Disintegrin And Metalloproteinase Domain-Containing Protein 22; Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein 2
Matching Pairs
Unconjugated Antibody: A Disintegrin And Metalloprotease 22 (MBS2032276)
APC-CY7 Conjugated Secondary Antibody: Immunoglobulin G (MBS2090675)
Matching Pairs
Unconjugated Antibody: A Disintegrin And Metalloprotease 22 (MBS2032276)
Unconjugated Secondary Antibody: Immunoglobulin G (MBS2090678)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
342
OMIM
AB009671 mRNA
3D Structure
ModBase 3D Structure for Q9P0K1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Pig
Specificity
The antibody is a rabbit polyclonal antibody raised against ADAM22. It has been selected for its ability to recognize ADAM22 in immunohistochemical staining and western blotting.
Purity/Purification
Affinity Chromatography
Form/Format
Supplied as solution form in PBS, pH7.4 containing 0.02% NaN3, 50% glycerol.
Concentration
200ug/ml (lot specific)
Immunoglobulin Type
IgG
Conjugate
No Conjugate
Organism Species
Human
Fragment
ADAM22 (Leu370~Asn582)
Quality Control
Content: The quality control contains recombinant ADAM22 (Leu370~Asn582) disposed in loading buffer.
Usage: 10uL per well when 3,3'-Diaminobenzidine(DAB) as the substrate.
5uL per well when used in enhanced chemilumescent (ECL).
Note: The quality control is specifically manufactured as the positive control.Not used for other purposes.
Loading Buffer: 100mM Tris(pH8.8), 2% SDS, 200mM NaCl, 50% glycerol,BPB 0.01%, NaN3 0.02%.
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2082045
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Other Notes
Small volumes of anti-ADAM22 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ADAM22 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)
Application Notes for anti-ADAM22 antibody
Western Blot: 1:50-400
Immunohistochemistry in formalin fixed frozen section: 1:50-500
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-ADAM22 antibody
Western Blot: Sample: Porcine Cerebrum lysate; Primary Ab: 1ug/ml Rabbit Anti-Human ADAM22 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
anti-ADAM22 antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-ADAM22 antibody
Western Blot: Sample: Recombinant protein.
anti-ADAM22 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-ADAM22 antibody
DAB staining on IHC-P. Samples: Human Tissue)
anti-ADAM22 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for ADAM22. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
96,637 Da
NCBI Official Full Name
disintegrin and metalloproteinase domain-containing protein 22 isoform 4
NCBI Official Synonym Full Names
ADAM metallopeptidase domain 22
NCBI Official Symbol
ADAM22  [Similar Products]
NCBI Official Synonym Symbols
MDC2; ADAM 22
  [Similar Products]
NCBI Protein Information
disintegrin and metalloproteinase domain-containing protein 22
UniProt Protein Name
Disintegrin and metalloproteinase domain-containing protein 22
UniProt Synonym Protein Names
Metalloproteinase-disintegrin ADAM22-3; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2
UniProt Gene Name
ADAM22  [Similar Products]
UniProt Synonym Gene Names
MDC2; ADAM 22  [Similar Products]
NCBI Summary for ADAM22
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]
UniProt Comments for ADAM22
ADAM22: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7q21.12

Cellular Component: axon; integral component of membrane; plasma membrane

Molecular Function: integrin binding; metalloendopeptidase activity; protein binding

Biological Process: adult locomotory behavior; cell adhesion; central nervous system development; myelination in the peripheral nervous system; negative regulation of cell adhesion; proteolysis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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