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anti-TXNRD1 antibody :: Goat Thioredoxin Reductase 1 Polyclonal Antibody

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Catalog # MBS420651
Unit / Price
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  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

Thioredoxin Reductase 1 (TXNRD1), Polyclonal Antibody

Full Product Name

Goat anti-Thioredoxin Reductase 1 Antibody

Product Synonym Names
TXNRD1; thioredoxin reductase 1; TR1; TXNR; GRIM-12; MGC9145; TR; TRXR1; KM-102-derived reductase-like factor; oxidoreductase; thioredoxin reductase GRIM-12; TXNRD1 antibody; thioredoxin reductase 1 antibody; TR1 antibody; TXNR antibody; GRIM-12 antibody; MGC9145 antibody; TR antibody; TRXR1 antibody; KM-102-derived reductase-like factor antibody; oxidoreductase antibody; thioredoxin reductase GRIM-12 antibody; Thioredoxin Reductase 1; Thioredoxin Reductase 1
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
TKRSGASILQ AGC
OMIM
601112
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Pig
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence TKRSGASILQAGC, from the C Terminus of the protein sequence according to NP_003321.2; NP_877393.1; NP_877419.1; NP_877420.1; NP_001087240.1.
Epitope
C Terminus
Note
This antibody is expected to recognise reported isoform 1 (NP_003321.2), isoform 2 (NP_877393.1; NP_877419.1; NP_877420.1) and isoform 3 (NP_001087240.1)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-TXNRD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-TXNRD1 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-TXNRD1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 60kDa band observed in Human Placenta lysates (predicted MW of 57kDa according to NP_003321). Recommended for use at 0.1-1ug/ml.

Western Blot (WB) of anti-TXNRD1 antibody
Staining (0.1ug/ml) of Human Placenta lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
anti-TXNRD1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for TXNRD1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Manufactured in an ISO 9001:2015 Certified Laboratory.NP_877393.1; NP_877419.1; NP_877420.1; NP_001087240.1[Other Products]
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,873 Da
NCBI Official Full Name
thioredoxin reductase 1
NCBI Official Synonym Full Names
thioredoxin reductase 1
NCBI Official Symbol
TXNRD1  [Similar Products]
NCBI Official Synonym Symbols
TR; TR1; TXNR; TRXR1; GRIM-12
  [Similar Products]
NCBI Protein Information
thioredoxin reductase 1, cytoplasmic
UniProt Protein Name
Thioredoxin reductase 1, cytoplasmic
UniProt Synonym Protein Names
Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1
Protein Family
UniProt Gene Name
TXNRD1  [Similar Products]
UniProt Synonym Gene Names
GRIM12; KDRF; TR; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein  [Similar Products]
UniProt Entry Name
TRXR1_HUMAN
NCBI Summary for TXNRD1
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for TXNRD1
TRXR1: a cytoplasmic pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine residue which is required for the catalytic activity.

Protein type: EC 1.8.1.9; Nuclear receptor co-regulator; Oxidoreductase; Nucleotide Metabolism - pyrimidine

Chromosomal Location of Human Ortholog: 12q23-q24.1

Cellular Component: cytosol; mitochondrion; nucleus

Molecular Function: electron carrier activity; FAD binding; protein binding; protein disulfide oxidoreductase activity; thioredoxin-disulfide reductase activity

Biological Process: cell proliferation; cell redox homeostasis; mesoderm formation; nucleobase, nucleoside and nucleotide interconversion; response to reactive oxygen species; selenium metabolic process; signal transduction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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