NP_000747.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
corticoliberin preproprotein
NCBI Official Synonym Full Names
corticotropin releasing hormone
NCBI Official Synonym Symbols
NCBI Protein Information
corticoliberin; OTTHUMP00000226787; corticotropin-releasing factor
UniProt Protein Name
Corticoliberin
UniProt Synonym Protein Names
Corticotropin-releasing factor; CRF; Corticotropin-releasing hormone
UniProt Entry Name
CRF_HUMAN
NCBI Summary for CRH
Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq]
UniProt Comments for CRH
Function: This hormone from hypothalamus regulates the release of corticotropin from pituitary gland.
Subunit structure: Interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain). Ref.9
Subcellular location: Secreted.
Sequence similarities: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
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Products associated with anti-CRH antibody
Pathways associated with anti-CRH antibody
Diseases associated with anti-CRH antibody
Organs/Tissues associated with anti-CRH antibody
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