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anti-KIAA0141 antibody :: Rabbit anti-Human, Rat DELE Polyclonal Antibody

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Catalog # MBS151106
Unit / Price
  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

DELE (KIAA0141), Polyclonal Antibody

Also Known As

DELE Antibody

Product Synonym Names
DELE; DELE; DELE; Death ligand signal enhancer; KIAA0141
Antibody/Peptide Pairs
DELE peptide (MBS151815) is used for blocking the activity of DELE antibody (MBS151106)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
515
OMIM
615741
3D Structure
ModBase 3D Structure for Q14154
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Rat
Purity/Purification
DELE Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (lot specific)
Conjugate
Unconjugated
Immunogen
DELE antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human DELE.
Buffer
DELE Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
DELE antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-KIAA0141 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KIAA0141 antibody
DELE Antibody: DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-α and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-α, anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.
Applications Tested/Suitable for anti-KIAA0141 antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-KIAA0141 antibody
DELE antibody can be used for detection of DELE by Western blot at 1 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-KIAA0141 antibody
Western blot analysis of DELE in rat brain tissue lysate with DELE antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
anti-KIAA0141 antibody Western Blot (WB) (WB) image
Immunofluorescence (IF) of anti-KIAA0141 antibody
Immunofluorescence of DELE in human brain tissue with DELE antibody at 20 μg/mL.
anti-KIAA0141 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for KIAA0141. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55,920 Da
NCBI Official Full Name
death ligand signal enhancer
NCBI Official Synonym Full Names
KIAA0141
NCBI Official Symbol
KIAA0141  [Similar Products]
NCBI Official Synonym Symbols
NCBI Protein Information
death ligand signal enhancer
UniProt Protein Name
Death ligand signal enhancer
Protein Family
UniProt Gene Name
KIAA0141  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
DELE_HUMAN
UniProt Comments for KIAA0141
KIAA0141: Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.

Chromosomal Location of Human Ortholog: 5q31.3

Cellular Component: mitochondrion

Molecular Function: protein binding

Biological Process: induction of apoptosis via death domain receptors; regulation of caspase activity
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Diseases associated with anti-KIAA0141 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1 publications with KIAA0141 and Necrosis
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