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anti-ELOVL4 antibody :: Rabbit anti-Human, Rat ELOVL4 Polyclonal Antibody

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Catalog # MBS7051324
Unit / Price
Scan QR to view Datasheet
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

ELOVL4, Polyclonal Antibody

Popular Item
Full Product Name

ELOVL4 Antibody

Product Synonym Names
Elongation of very long chain fatty acids protein 4; 3-keto acyl-CoA synthase ELOVL4; ELOVL4
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
3D Structure
ModBase 3D Structure for Q9GZR5
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Rat
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Immunogen
Recombinant Human Elongation of very long chain fatty acids protein 4 protein (270-314AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Conjugation
Non-conjugated
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-49192 / sc-49193 / sc-67215
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-ELOVL4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ELOVL4 antibody
Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that specifically elongates C24: 0 and C26: 0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.
Applications Tested/Suitable for anti-ELOVL4 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-ELOVL4 antibody
WB: 1: 500-1: 5000
IHC: 1: 20-1: 200
IF: 1: 50-1: 200

Western Blot (WB) of anti-ELOVL4 antibody
Western Blot
Positive WB detected in: HepG2 whole cell lysate,Rat heart tissue,Rat liver tissue
All lanes: ELOVL4 antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 37 KDa
Observed band size: 37 KDa

anti-ELOVL4 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-ELOVL4 antibody
Immunohistochemistry of paraffin-embedded human testis tissue using MBS7051324 at dilution of 1:100
anti-ELOVL4 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-ELOVL4 antibody
Immunohistochemistry of paraffin-embedded human small intestine tissue using MBS7051324 at dilution of 1:100
anti-ELOVL4 antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-ELOVL4 antibody
Immunofluorescent analysis of HepG2 cells using MBS7051324 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-ELOVL4 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for ELOVL4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,829 Da
NCBI Official Full Name
elongation of very long chain fatty acids protein 4
NCBI Official Synonym Full Names
ELOVL fatty acid elongase 4
NCBI Official Symbol
ELOVL4  [Similar Products]
NCBI Official Synonym Symbols
ADMD; CT118; ISQMR; SCA34; STGD2; STGD3
  [Similar Products]
NCBI Protein Information
elongation of very long chain fatty acids protein 4
UniProt Protein Name
Elongation of very long chain fatty acids protein 4
UniProt Synonym Protein Names
3-keto acyl-CoA synthase ELOVL4
UniProt Gene Name
ELOVL4  [Similar Products]
UniProt Synonym Gene Names
ELOVL FA elongase 4  [Similar Products]
UniProt Entry Name
ELOV4_HUMAN
NCBI Summary for ELOVL4
This gene encodes a membrane-bound protein which is a member of the ELO family, proteins which participate in the biosynthesis of fatty acids. Consistent with the expression of the encoded protein in photoreceptor cells of the retina, mutations and small deletions in this gene are associated with Stargardt-like macular dystrophy (STGD3) and autosomal dominant Stargardt-like macular dystrophy (ADMD), also referred to as autosomal dominant atrophic macular degeneration. [provided by RefSeq, Jul 2008]
UniProt Comments for ELOVL4
ELOVL4: Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs). Elongates C24:0 and C26:0 acyl-CoAs. Seems to represent a photoreceptor- specific component of the fatty acid elongation system residing on the endoplasmic reticulum. May be implicated in docosahexaenoic acid (DHA) biosynthesis, which requires dietary consumption of the essential alpha-linolenic acid and a subsequent series of three elongation steps. May play a critical role in early brain and skin development. Defects in ELOVL4 are the cause of Stargardt disease type 3 (STGD3). STGD is one of the most frequent causes of macular degeneration in childhood. It is characterized by macular dystrophy with juvenile-onset, rapidly progressive course, alterations of the peripheral retina, and subretinal deposition of lipofuscin-like material. STGD3 inheritance is autosomal dominant. Defects in ELOVL4 are the cause of ichthyosis, spastic quadriplegia, and mental retardation (ISQMR). A severe autosomal recessive disorder characterized by ichthyosis apparent from birth, profound psychomotor retardation with essentially no development, spastic quadriplegia, and seizures. Belongs to the ELO family.

Protein type: Cancer Testis Antigen (CTA); EC 2.3.1.199; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6q14

Cellular Component: endoplasmic reticulum; integral to endoplasmic reticulum membrane

Molecular Function: fatty acid elongase activity; protein binding

Biological Process: fatty acid elongation, saturated fatty acid; sphingolipid biosynthetic process; very-long-chain fatty acid biosynthetic process

Disease: Spinocerebellar Ataxia 34
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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