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anti-GAD1 antibody :: Rabbit anti-Human, Rat Glutamate decarboxylase 1 Polyclonal Antibody

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Catalog # MBS1492729
Unit / Price
  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

Glutamate decarboxylase 1 (GAD1), Polyclonal Antibody

Popular Item
Also Known As

Rabbit anti-human Glutamate decarboxylase 1 polyclonal Antibody(GAD1)

Product Synonym Names
67 kDa glutamic acid decarboxylase; GAD-67; Glutamate decarboxylase 67 kDa isoform; GAD1; GAD; GAD67
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
3D Structure
ModBase 3D Structure for Q99259
Species Reactivity
Human, Rat
Antigen Affinity Purified
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recombinant human Glutamate decarboxylase 1 protein (1-200aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-7512 / sc-7513 / sc-5602
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-GAD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GAD1 antibody
Catalyzes the production of GABA.
Applications Tested/Suitable for anti-GAD1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-GAD1 antibody
Recommended dilution: WB:1:500-2000

Western Blot (WB) of anti-GAD1 antibody
All lanes: Glutamate decarboxylase 1 antibody at 10ug/ml+rat brain tissue
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 67,26,48 kDa
Observed band size: 67 kDa

anti-GAD1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-GAD1 antibody
Immunohistochemistry of paraffin-embedded human breast cancer using MBS1492729 at dilution 1:100
anti-GAD1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for GAD1. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,440 Da
NCBI Official Full Name
glutamate decarboxylase 1 isoform GAD67
NCBI Official Synonym Full Names
glutamate decarboxylase 1
NCBI Official Symbol
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
glutamate decarboxylase 1
UniProt Protein Name
Glutamate decarboxylase 1
UniProt Synonym Protein Names
67 kDa glutamic acid decarboxylase; GAD-67; Glutamate decarboxylase 67 kDa isoform
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
GAD; GAD67; GAD-67  [Similar Products]
UniProt Entry Name
NCBI Summary for GAD1
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008]
UniProt Comments for GAD1
GAD67: Catalyzes the production of GABA. Homodimer. Isoform 3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain. Belongs to the group II decarboxylase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Other Amino Acids Metabolism - taurine and hypotaurine; Carbohydrate Metabolism - butanoate; Mitochondrial; Amino Acid Metabolism - alanine, aspartate and glutamate; Lyase; EC; Other Amino Acids Metabolism - beta-alanine

Chromosomal Location of Human Ortholog: 2q31

Cellular Component: intracellular; plasma membrane; presynaptic active zone; vesicle membrane

Molecular Function: glutamate binding; glutamate decarboxylase activity; protein binding; protein heterodimerization activity; protein N-terminus binding; pyridoxal phosphate binding

Biological Process: gamma-aminobutyric acid biosynthetic process; glutamate catabolic process; glutamate decarboxylation to succinate; neurotransmitter biosynthetic process; neurotransmitter secretion; protein-pyridoxal-5-phosphate linkage; response to drug; synaptic transmission

Disease: Cerebral Palsy, Spastic Quadriplegic, 1
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