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anti-MEF2C antibody :: Rabbit anti-Human, Rat MEF2C Polyclonal Antibody

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Catalog # MBS176264
Unit / Price
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  0.1 mg  /  $315 +1 FREE 8GB USB
Product Name

MEF2C, Polyclonal Antibody

Popular Item
Full Product Name

Anti-MEF2C antibody

Product Synonym Names
Myocyte-specific enhancer factor 2C; myocyte enhancer factor 2C; C5DELq14.3 antibody; DEL5q14.3 antibody; MADS box transcription enhancer factor 2 polypeptide C(myocyte enhancer factor 2C) antibody; MEF2C antibody; MEF2C_HUMAN antibody; Myocyte enhancer factor 2C antibody; Myocyte specific enhancer factor 2C antibody; Myocyte-specific enhancer factor 2C antibody; OTTHUMP00000222409 antibody; Similar to MADS box transcription enhancer factor 2 polypeptide C antibody
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
gene 613443
3D Structure
ModBase 3D Structure for Q06413
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Rat
Specificity
No cross reactivity with other proteins.
Purity/Purification
Immunogen affinity purified.
Form/Format
Lyophilized
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human MEF2C (406-419aa SRYPQHTRHEAGRS), identical to the related rat sequence.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-MEF2C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MEF2C antibody
Description: Rabbit IgG polyclonal antibody for Myocyte-specific enhancer factor 2C(MEF2C) detection. Tested with WB, IHC-P in Human, Rat.
Background: MEF2C(myocyte enhancer factor 2C) also called  MADS box transcription enhancer factor 2, polypeptide C, is a protein that in humans is encoded by the MEF2C gene. MEF2C is a transcription factor in the Mef2 family.MEF2C, however, is induced late during myogenic differentiation and has a strict tissue-specific pattern of expression not seen in MEF2A or MEF2B. By fluorescence in situ hybridization, the human MEF2C is mapped to chromosome 5q14, a region with homology of synteny to the mouse location.MEF2C may be involved with maintenance of the differentiated state. Both MEF2A and Mef2c programmed similar profiles of gene expression in the heart that included genes involved in extracellular matrix remodeling, ion handling, and metabolism. NCOA2 mediates the coactivation of MEF2C-dependent transcription through interaction with the MADS box domain of MEF2C. 
Applications Tested/Suitable for anti-MEF2C antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Application Notes for anti-MEF2C antibody
Western Blot:
Concentration: 0.1-0.5ug/ml
Tested Species: Hu, Rat

Immunohistochemistry (Paraffin-embedded Section):
Concentration:0.5-1ug/ml
Tested Species: Hu, Rat
Antigen Retrieval: By Heat

Tested Species: In-house tested species with positive results.
Predicted Species: Species predicted to be fit for the product based on sequence similarities.
By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20 mins is required for the staining of formalin/paraffin sections. Other applications have not been tested Optimal dilutions should be determined by end users.

Immunohistochemistry (IHC) of anti-MEF2C antibody
Anti-MEF2C antibody, MBS176264, IHC(P)
IHC(P): Human Intestine Tissue
anti-MEF2C antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-MEF2C antibody
Anti-MEF2C antibody, MBS176264, Western blotting
Lane 1: Rat Testis Tissue Lysate
Lane 2: COLO320 Cell Lysate

anti-MEF2C antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for MEF2C. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,242 Da
NCBI Official Full Name
Myocyte-specific enhancer factor 2C
NCBI Official Synonym Full Names
myocyte enhancer factor 2C
NCBI Official Symbol
MEF2C  [Similar Products]
NCBI Official Synonym Symbols
DEL5q14.3; C5DELq14.3
  [Similar Products]
NCBI Protein Information
myocyte-specific enhancer factor 2C; MADS box transcription enhancer factor 2, polypeptide C
UniProt Protein Name
Myocyte-specific enhancer factor 2C
UniProt Gene Name
MEF2C  [Similar Products]
UniProt Entry Name
MEF2C_HUMAN
NCBI Summary for MEF2C
This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe mental retardation, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]
UniProt Comments for MEF2C
MEF2C: transcription factor of the MADS family which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. May be involved in myogenesis, neurogenesis and in the development of cortical architecture. Three splice-variant isoforms have been described.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 5q14.3

Cellular Component: nucleoplasm; protein complex; intracellular membrane-bound organelle; cytoplasm; nuclear speck; cytosol; nucleus

Molecular Function: protein binding; miRNA binding; transcription activator binding; DNA binding; AT DNA binding; protein heterodimerization activity; histone deacetylase binding; chromatin binding; transcription factor activity

Biological Process: cardiac muscle hypertrophy; muscle development; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; heart development; stress-activated MAPK cascade; regulation of neurotransmitter secretion; regulation of synaptic plasticity; toll-like receptor 3 signaling pathway; neuron differentiation; toll-like receptor 5 signaling pathway; positive regulation of MAP kinase activity; B cell receptor signaling pathway; regulation of neuron apoptosis; positive regulation of B cell proliferation; negative regulation of ossification; chondrocyte differentiation; negative regulation of neuron apoptosis; toll-like receptor 4 signaling pathway; positive regulation of cardiac muscle cell proliferation; endochondral ossification; nervous system development; skeletal muscle development; monocyte differentiation; response to virus; myotube differentiation; positive regulation of skeletal muscle development; muscle cell fate determination; toll-like receptor 2 signaling pathway; muscle cell differentiation; regulation of synaptogenesis; neuron development; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; transcription from RNA polymerase II promoter; B cell proliferation; regulation of synaptic transmission, glutamatergic; apoptosis; neuron migration; ventricular cardiac muscle cell differentiation; regulation of synaptic activity; palate development; negative regulation of transcription from RNA polymerase II promoter; toll-like receptor 10 signaling pathway; learning and/or memory; regulation of transcription, DNA-dependent; B cell homeostasis; melanocyte differentiation; regulation of megakaryocyte differentiation; germinal center formation; heart looping; neural crest cell differentiation; negative regulation of epithelial cell proliferation; blood vessel development; MyD88-independent toll-like receptor signaling pathway; MAPKKK cascade; embryonic viscerocranium morphogenesis; positive regulation of bone mineralization; humoral immune response; regulation of germinal center formation; positive regulation of myoblast differentiation; MyD88-dependent toll-like receptor signaling pathway; osteoblast differentiation; positive regulation of osteoblast differentiation; neuron morphogenesis during differentiation; toll-like receptor signaling pathway; innate immune response; positive regulation of muscle cell differentiation; blood vessel remodeling; platelet formation; regulation of excitatory postsynaptic membrane potential; positive regulation of neuron differentiation

Disease: Mental Retardation, Autosomal Dominant 20
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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