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anti-PBR antibody :: Rabbit anti-Human, Rat PBR Polyclonal Antibody

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Catalog # MBS5400187
Unit / Price
  0.1 mg Biotin  /  $495 +1 FREE 8GB USB
anti-PBR antibody
Product Name

PBR, Polyclonal Antibody

Popular Item
Also Known As

PBR Antibody BIOTIN-Conjugated

Product Synonym Names
Benzodiazapine receptor (peripheral); Benzodiazepine peripheral binding site; BPBS; BZRP; DBI; IBP; Isoquinoline carboxamide-binding protein; MBR; mDRC; Mitochondrial benzodiazepine receptor; PBR; PBS; Peripheral benzodiazepine receptor; Peripheral benzodiazepine receptor-related protein; pk18; PKBS; PTBR; Ptbzr; PTBZR02; RATPTBZR02; translocator protein (18kDa); Translocator protein; TSPO; Tspo1 antibody
Product Gene Name
Matching Pairs
Antibody: PBR (MBS5400187)
Positive Control: PBR (MBS543359)
Antibody/Peptide Pairs
PBR peptide (MBS544627) is used for blocking the activity of PBR antibody (MBS5400187)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
169
OMIM
109610
3D Structure
ModBase 3D Structure for P30536
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Rat
Form/Format
BIOTIN-Conjugated
Concentration
0.60-0.65 ug/ul in antibody stabilization buffer (lot specific)
Immunogen
Synthetic peptide taken within amino acid region 100-150 on 18 kDa mitochondrial benzodiazepine receptor protein.
Expression
Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids
Molecular Function
Benzodiazepine receptor activity, cholesterol binding
Subcellular Location
Mitochondrian membrane, Multi-pass membrane protein
Preparation and Storage
-20 degree C for long term storage
Other Notes
Small volumes of anti-PBR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PBR antibody
BIOTIN-Conjugated Mitochondrial benzodiazepine receptor Antibody
Can bind protoporphyrin IX and may play a role in transport of porphyrins and heme. Promotes transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism.
Applications Tested/Suitable for anti-PBR antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-PBR antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunohistochemistry: 1:100
Immunoprecipitation: 1:200
Western Blot: 1:500
NCBI/Uniprot data below describe general gene information for PBR. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,537 Da
NCBI Official Full Name
Translocator protein
NCBI Official Synonym Full Names
translocator protein
NCBI Official Symbol
NCBI Official Synonym Symbols
DBI; IBP; MBR; PBR; PBS; BPBS; BZRP; PKBS; PTBR; mDRC; pk18
  [Similar Products]
NCBI Protein Information
translocator protein
UniProt Protein Name
Translocator protein
UniProt Synonym Protein Names
Mitochondrial benzodiazepine receptor; PKBS; Peripheral-type benzodiazepine receptor; PBR
UniProt Gene Name
UniProt Synonym Gene Names
BZRP; MBR; PBR  [Similar Products]
UniProt Entry Name
TSPOA_HUMAN
NCBI Summary for PBR
Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. [provided by RefSeq, Feb 2012]
UniProt Comments for PBR
TSPO: Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells. Belongs to the TspO/BZRP family. Interacts with BZRAP1. May interact with STAR. Interacts with MOST-1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Receptor, misc.; Membrane protein, integral; Apoptosis; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: cytoplasm; integral to membrane; intracellular membrane-bound organelle; mitochondrial outer membrane; mitochondrion; nuclear membrane

Molecular Function: androgen binding; benzodiazepine receptor activity; cholesterol binding; protein binding

Biological Process: adrenal gland development; aging; anion transport; apoptosis; axon regeneration in the peripheral nervous system; behavioral response to pain; cell proliferation; chloride transport; glial cell migration; heme biosynthetic process; lipid transport; negative regulation of nitric oxide biosynthetic process; negative regulation of protein ubiquitination; negative regulation of tumor necrosis factor production; positive regulation of apoptosis; positive regulation of calcium ion transport; positive regulation of mitochondrial depolarization; protein targeting to mitochondrion; regulation of cholesterol transport; regulation of steroid biosynthetic process; response to drug; response to manganese ion; response to progesterone stimulus; response to testosterone stimulus; response to vitamin B1; steroid biosynthetic process; steroid metabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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