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anti-PSEN2 antibody :: Rabbit anti-Human, Rat PSEN2 Polyclonal Antibody

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Catalog # MBS7052325
Unit / Price
Scan QR to view Datasheet
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Western Blot (WB)
Product Name

PSEN2, Polyclonal Antibody

Popular Item
Full Product Name

PSEN2 Antibody

Product Synonym Names
Presenilin-2; PS-2; AD3LP; AD5; E5-1; STM-2; Presenilin-2 NTF subunit; Presenilin-2 CTF subunit; PSEN2; AD4; PS2; PSNL2; STM2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
L43964 mRNA
3D Structure
ModBase 3D Structure for P49810
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Rat
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Immunogen
Recombinant Human Presenilin-2 protein (7-77AA)
Conjugation
Non-conjugated
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-PSEN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PSEN2 antibody
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
Applications Tested/Suitable for anti-PSEN2 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-PSEN2 antibody
WB: 1:500-1:5000

Western Blot (WB) of anti-PSEN2 antibody
Western Blot
Positive WB detected in: Rat spleen tissue,Rat lung tissue
All lanes: PSEN2 antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 51,47 KDa
Observed band size: 51 KDa

anti-PSEN2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for PSEN2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,011 Da
NCBI Official Full Name
presenilin-2 isoform 1
NCBI Official Synonym Full Names
presenilin 2
NCBI Official Symbol
PSEN2  [Similar Products]
NCBI Official Synonym Symbols
AD4; PS2; AD3L; STM2; CMD1V
  [Similar Products]
NCBI Protein Information
presenilin-2
UniProt Protein Name
Presenilin-2
UniProt Synonym Protein Names
AD3LP; AD5; E5-1; STM-2
Protein Family
UniProt Gene Name
PSEN2  [Similar Products]
UniProt Synonym Gene Names
AD4; PS2; PSNL2; STM2; PS-2  [Similar Products]
NCBI Summary for PSEN2
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for PSEN2
PSEN2: probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). An integral membrane protein of the Golgi and endoplasmic reticulum. Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. Two alternative splice isoforms have been identified.

Protein type: Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Protease

Chromosomal Location of Human Ortholog: 1q42.13

Cellular Component: apical plasma membrane; cell cortex; cell soma; centrosome; endoplasmic reticulum; Golgi apparatus; integral to plasma membrane; kinetochore; membrane; nuclear inner membrane; perinuclear region of cytoplasm; plasma membrane; protein complex; Z disc

Molecular Function: endopeptidase activity; protein binding

Biological Process: amyloid precursor protein catabolic process; beta-amyloid metabolic process; calcium ion transport; ephrin receptor signaling pathway; membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; negative regulation of apoptosis; Notch receptor processing; Notch signaling pathway; positive regulation of apoptosis; positive regulation of catalytic activity; protein processing

Disease: Alzheimer Disease 4; Cardiomyopathy, Dilated, 1v
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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