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anti-SOCS7 antibody :: Rabbit anti-Human, Rat SOCS7 Polyclonal Antibody

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Catalog # MBS7052417
Unit / Price
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  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

SOCS7, Polyclonal Antibody

Popular Item
Full Product Name

SOCS7 Antibody

Product Synonym Names
Suppressor of cytokine signaling 7; SOCS-7; Nck; Ash and phospholipase C gamma-binding protein; Nck-associated protein 4; NAP-4; SOCS7; NAP4; SOCS6
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
AB005216 mRNA
3D Structure
ModBase 3D Structure for O14512
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Rat
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Immunogen
Recombinant Human Suppressor of cytokine signaling 7 protein (6-165AA)
Conjugation
Non-conjugated
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-SOCS7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SOCS7 antibody
Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Applications Tested/Suitable for anti-SOCS7 antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-SOCS7 antibody
WB: 1:500-1:5000
IF: 1:50-1:200

Western Blot (WB) of anti-SOCS7 antibody
Western Blot
Positive WB detected in: MCF-7 whole cell lysate,Hela whole cell lysate,Jurkat whole cell lysate,U87 whole cell lysate,Rat heart tissue,Rat liver tissue
All lanes: SOCS7 antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 63,38 KDa
Observed band size: 63 KDa

anti-SOCS7 antibody Western Blot (WB) (WB) image
Immunofluorescence (IF) of anti-SOCS7 antibody
Immunofluorescent analysis of HepG2 cells using MBS7052417 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-SOCS7 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for SOCS7. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
37,461 Da
NCBI Official Full Name
suppressor of cytokine signaling 7
NCBI Official Synonym Full Names
suppressor of cytokine signaling 7
NCBI Official Symbol
SOCS7  [Similar Products]
NCBI Official Synonym Symbols
NAP4; NCKAP4
  [Similar Products]
NCBI Protein Information
suppressor of cytokine signaling 7
UniProt Protein Name
Suppressor of cytokine signaling 7
UniProt Synonym Protein Names
Nck, Ash and phospholipase C gamma-binding protein; Nck-associated protein 4; NAP-4
UniProt Gene Name
SOCS7  [Similar Products]
UniProt Synonym Gene Names
NAP4; SOCS6; SOCS-7; NAP-4  [Similar Products]
UniProt Comments for SOCS7
SOCS7: Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF- like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: cytoplasm

Molecular Function: protein binding; protein kinase inhibitor activity

Biological Process: cytokine and chemokine mediated signaling pathway; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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