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anti-STRADA antibody :: Rabbit anti-Human, Rat STRADA Polyclonal Antibody

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Catalog # MBS7045576
Unit / Price
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  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

STRADA, Polyclonal Antibody

Popular Item
Full Product Name

STRADA Antibody

Product Synonym Names
STE20-related kinase adapter protein alpha; STRAD alpha; STE20-related adapter protein; Serologically defined breast cancer antigen NY-BR-96; STRADA; LYK5
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
608626
3D Structure
ModBase 3D Structure for Q7RTN6
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Rat
Purity/Purification
Antigen Affinity Purified
Form/Format
Liquid
Species
Human
Immunogen
Recombinant human STE20-related kinase adapter protein alpha protein (25-210AA)
Conjugate
Non-conjugated
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-55052 / sc-34102 / sc-34103 / sc-130882 / sc-99155
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-STRADA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-STRADA antibody
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.
Applications Tested/Suitable for anti-STRADA antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-STRADA antibody
Western blot
All lanes: STRADA antibody IgG at 1.98ug/ml+ Rat heart tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 49,39,44,34,42,35 kDa
Observed band size: 48 kDa

anti-STRADA antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-STRADA antibody
Immunohistochemistry of paraffin-embedded human brain tissue using MBS7045576 at dilution 1:100
anti-STRADA antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-STRADA antibody
Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7045576 at dilution 1:100
anti-STRADA antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for STRADA. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,625 Da
NCBI Official Full Name
STE20-related kinase adapter protein alpha isoform 2
NCBI Official Synonym Full Names
STE20-related kinase adaptor alpha
NCBI Official Symbol
STRADA  [Similar Products]
NCBI Official Synonym Symbols
LYK5; PMSE; Stlk; STRAD; NY-BR-96
  [Similar Products]
NCBI Protein Information
STE20-related kinase adapter protein alpha
UniProt Protein Name
STE20-related kinase adapter protein alpha
UniProt Synonym Protein Names
STE20-related adapter protein; Serologically defined breast cancer antigen NY-BR-96
UniProt Gene Name
STRADA  [Similar Products]
UniProt Synonym Gene Names
; STRAD alpha  [Similar Products]
UniProt Entry Name
STRAA_HUMAN
NCBI Summary for STRADA
The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]
UniProt Comments for STRADA
STRAD: a pseudokinase which, in complex with CAB39, binds to and activates LKB1. Relocates LKB1 from the nucleus to the cytoplasm. Plays an essential role in LKB1-mediated G1 cell cycle arrest. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; Motility/polarity/chemotaxis; STE group; STE20 family; STLK subfamily

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: kinase binding; protein binding; protein kinase activator activity; protein kinase activity; protein serine/threonine kinase activator activity

Biological Process: activation of protein kinase activity; cell cycle arrest; protein amino acid phosphorylation; protein export from nucleus

Disease: Polyhydramnios, Megalencephaly, And Symptomatic Epilepsy
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-STRADA antibody
 Reference Product  PubMed Publications
 STK11 antibody  >1 publications with STRADA and STK11
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