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anti-TXK antibody :: Rabbit anti-Human, Rat TXK Polyclonal Antibody

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Catalog # MBS7052473
Unit / Price
Scan QR to view Datasheet
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

TXK, Polyclonal Antibody

Popular Item
Full Product Name

TXK Antibody

Product Synonym Names
Tyrosine-protein kinase TXK; Protein-tyrosine kinase 4; Resting lymphocyte kinase; TXK; PTK4; RLK
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
L27071 mRNA
3D Structure
ModBase 3D Structure for P42681
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Rat
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Immunogen
Recombinant Human Tyrosine-protein kinase TXK protein (32-83AA)
Conjugation
Non-conjugated
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-TXK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TXK antibody
Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.
Applications Tested/Suitable for anti-TXK antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-TXK antibody
WB: 1:500-1:5000
IHC: 1:20-1:200
IF: 1:50-1:200

Western Blot (WB) of anti-TXK antibody
Western Blot
Positive WB detected in: HEK293 whole cell lysate,Jurkat whole cell lysate,Rat liver tissue,Rat stomach tissue
All lanes: TXK antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 62 KDa
Observed band size: 62 KDa

anti-TXK antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-TXK antibody
Immunohistochemistry of paraffin-embedded human lymph node tissue using MBS7052473 at dilution of 1:100
anti-TXK antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-TXK antibody
Immunohistochemistry of paraffin-embedded human breast cancer using MBS7052473 at dilution of 1:100
anti-TXK antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-TXK antibody
Immunofluorescent analysis of HepG2 cells using MBS7052473 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-TXK antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for TXK. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
61,258 Da
NCBI Official Full Name
tyrosine-protein kinase TXK
NCBI Official Synonym Full Names
TXK tyrosine kinase
NCBI Official Symbol
NCBI Official Synonym Symbols
RLK; TKL; BTKL; PTK4; PSCTK5
  [Similar Products]
NCBI Protein Information
tyrosine-protein kinase TXK
UniProt Protein Name
Tyrosine-protein kinase TXK
UniProt Synonym Protein Names
Protein-tyrosine kinase 4; Resting lymphocyte kinase
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
PTK4; RLK  [Similar Products]
UniProt Comments for TXK
TXK: Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T- cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskekleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell- specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr- 201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor. Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.

Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Tec family

Chromosomal Location of Human Ortholog: 4p12

Cellular Component: cytoplasm; extrinsic to internal side of plasma membrane; nucleus

Molecular Function: protein binding; receptor binding

Biological Process: adaptive immune response; cell differentiation; cytokine production; integrin-mediated signaling pathway; phospholipase C activation; positive regulation of interferon-gamma production; positive regulation of transcription from RNA polymerase II promoter; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; T cell receptor signaling pathway; tissue regeneration; transmembrane receptor protein tyrosine kinase signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withanti-TXK antibody
 Reference Product  PubMed Publications
 PIK3R1 antibody  >1 publications with TXK and PIK3R1
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