NP_001152790.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
interleukin-1 receptor accessory protein isoform d
NCBI Official Synonym Full Names
interleukin 1 receptor accessory protein
NCBI Official Synonym Symbols
AI255955; AV239853; IL-1RAcP; 6430709H04Rik [Similar Products]
NCBI Protein Information
interleukin-1 receptor accessory protein
UniProt Protein Name
Interleukin-1 receptor accessory protein
UniProt Synonym Protein Names
Interleukin-33 receptot beta chain
UniProt Synonym Gene Names
UniProt Comments for IL1RAP
IL1RAP: Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Belongs to the interleukin-1 receptor family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 16|16 B2
Cellular Component: cytoplasm; extracellular region; extracellular space; integral component of membrane; membrane; plasma membrane; protein complex
Molecular Function: interleukin-1 receptor activity; interleukin-1 receptor binding; protein binding; signal transducer activity
Biological Process: cytokine-mediated signaling pathway; immune system process; inflammatory response; innate immune response; interleukin-2 biosynthetic process; positive regulation of interleukin-13 production; positive regulation of interleukin-5 production; positive regulation of NF-kappaB transcription factor activity; positive regulation of synaptogenesis; signal transduction
Research Articles on IL1RAP
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Pathways associated with anti-IL1RAP antibody
Diseases associated with anti-IL1RAP antibody
Organs/Tissues associated with anti-IL1RAP antibody
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