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anti-Orm1 antibody :: Sheep anti-Mouse a1-Acid Glycoprotein Polyclonal Antibody

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Catalog # MBS619485
Unit / Price
  0.1 mg  /  $765 +1 FREE 8GB USB
anti-Orm1 antibody
Product Name

a1-Acid Glycoprotein (Orm1), Polyclonal Antibody

Full Product Name

a1-Acid Glycoprotein (Orosomucoid)

Product Synonym Names
Anti -a1-Acid Glycoprotein (Orosomucoid)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 5; NC_005104.2 (80325042..80328194). Location: 5q24
3D Structure
ModBase 3D Structure for P02764
Clonality
Polyclonal
Isotype
IgG
Host
Sheep
Species Reactivity
Mouse
Specificity
Recognizes mouse a1-Acid Glycoprotein. Species Sequence Homology: rat; 70%, human; 47%.
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Form/Format
Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 500ul sterile PBS.
Immunogen
Mouse a1-Acid Glycoprotein (Accession # P02763) purified from mouse plasma.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-Orm1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Orm1 antibody
alpha 1-Acid Glycoprotein (AGP; also OMD/Orosomucoid) is a 40-46kD member of the immunocalin subfamily, lipocalin family of molecules. In mouse, circulating AGP is principally the product of hepatocytes that originates from multiple related genes (AGP-1, -2 & -3 in Mus musculus). Circulating AGP-1 and -2 are both 189aa in length, the principal sources of protein, and show 83% aa identity; AGP-3 contributes little to the AGP pool. In mouse blood, AGP is normally 200-400ug/ml. In response to inflammatory mediators (IL-6; IL-1), its concentration will rise 2 to 10 fold. More importantly, a complex glycosylation pattern will also change, transitioning from modestly branched to highly branched oligosaccharides. This change is reflected in its bioactivity, which has been shown to be a function of carbohydrate branching. AGP is generally considered to be a suppressor of inflammation. Rat and human AGP share only 70% and 47% aa identity with mouse AGP, respectively.
Applications Tested/Suitable for anti-Orm1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-Orm1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 0.5-1ug/ml. The detection limit is ~0.3ng/well.
Western Blot: 1ug/ml
NCBI/Uniprot data below describe general gene information for Orm1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
23,575 Da[Similar Products]
NCBI Official Full Name
alpha-1-acid glycoprotein
NCBI Official Synonym Full Names
orosomucoid 1
NCBI Official Symbol
NCBI Official Synonym Symbols
AGP; OMD; Orm; Agpa1
  [Similar Products]
NCBI Protein Information
alpha-1-acid glycoprotein
UniProt Protein Name
Alpha-1-acid glycoprotein
UniProt Synonym Protein Names
Orosomucoid
Protein Family
UniProt Gene Name
UniProt Entry Name
A1AG_RAT
NCBI Summary for Orm1
an acute phase reactant protein; may have a role in the acute inflammation response [RGD]
UniProt Comments for Orm1
ORM1: Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction. Belongs to the calycin superfamily. Lipocalin family.

Protein type: Secreted, signal peptide; Secreted

Cellular Component: extracellular space

Molecular Function: drug binding

Biological Process: response to drug; organ regeneration; response to vitamin E; regulation of immune system process; transport; acute-phase response; response to lipopolysaccharide; response to organic cyclic substance; chronic inflammatory response to antigenic stimulus; acute inflammatory response to antigenic stimulus
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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