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anti-Abl1 antibody :: Rabbit anti-Mouse Abl1 Polyclonal Antibody

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Catalog # MBS9203187
Unit / Price
  0.08 mL  /  $150 +1 FREE 8GB USB
  0.4 mL  /  $340 +1 FREE 8GB USB
Product Name

Abl1, Polyclonal Antibody

Also Known As

Mouse Abl1 Antibody (Center)

Product Synonym Names
Tyrosine-protein kinase ABL1; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150; Abl1; Abl
Antibody/Peptide Pairs
Abl1 peptide (MBS9220291) is used for blocking the activity of Abl1 antibody (MBS9203187)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
613-641
Immunogen Sequence Length
1,142
3D Structure
ModBase 3D Structure for P00520
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Mouse
Specificity
This Mouse Abl1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 613-641 amino acids from the Central region of mouse Abl1.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.43 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
MOUSE
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-Abl1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Abl1 antibody
Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
Product Categories/Family for anti-Abl1 antibody
Applications Tested/Suitable for anti-Abl1 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-Abl1 antibody
WB~~1:1000

Western Blot (WB) of anti-Abl1 antibody
Mouse Abl1 Antibody (Center) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the Abl1 antibody detected the Abl1 protein (arrow).
anti-Abl1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-Abl1 antibody
Mouse Abl1 Antibody (Center) (MBS9203187)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse duodenum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Abl1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
anti-Abl1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for Abl1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
122673
NCBI Official Full Name
tyrosine-protein kinase ABL1 isoform a
NCBI Official Synonym Full Names
c-abl oncogene 1, non-receptor tyrosine kinase
NCBI Official Symbol
NCBI Official Synonym Symbols
Abl; c-Abl; AI325092; E430008G22Rik
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NCBI Protein Information
tyrosine-protein kinase ABL1
UniProt Protein Name
Tyrosine-protein kinase ABL1
UniProt Synonym Protein Names
Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
ABL1_MOUSE
UniProt Comments for Abl1
Abl: an ubiquitously expressed and highly conserved proto-oncogenic tyrosine kinase. c-Abl protein is distributed in both the nucleus and the cytoplasm of cells. Negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. It has been implicated in regulation of cell proliferation, differentiation, apoptosis, cell adhesion and stress response. The Philadephia chromosome translocation t(9;22)(q34;q11) creates a Bcr-Abl fusion protein, responsible for 90% of chronic myelogenous leukemia (CML) and ~25% of acute lymphoblastic leukemia (ALL). Inhibitors: Gleevec (imatinib, Glivec), Dasatinib. Two alternatively-spliced isoforms have been described.

Protein type: Protein kinase, TK; Kinase, protein; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Oncoprotein; TK group; Abl family

Cellular Component: neuron projection; mitochondrion; endoplasmic reticulum; leading edge; cytosol; actin cytoskeleton; nucleoplasm; ruffle; extrinsic to internal side of plasma membrane; growth cone; cytoskeleton; cell soma; perinuclear region of cytoplasm; cytoplasm; nucleolus; synapse; nucleus

Molecular Function: protein C-terminus binding; protein domain specific binding; metal ion binding; magnesium ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein kinase binding; protein kinase activity; transferase activity; actin filament binding; protein binding; DNA binding; syntaxin binding; protein-tyrosine kinase activity; manganese ion binding; transferase activity, transferring phosphorus-containing groups; mitogen-activated protein kinase binding; kinase activity; SH3 domain binding; ATP binding; receptor binding

Biological Process: B cell proliferation; peptidyl-tyrosine phosphorylation; DNA damage induced protein phosphorylation; regulation of cell cycle; apoptosis; positive regulation of apoptosis; cerebellum morphogenesis; alpha-beta T cell differentiation; platelet-derived growth factor receptor signaling pathway; positive regulation of mitotic cell cycle; protein amino acid phosphorylation; negative regulation of BMP signaling pathway; elevation of cytosolic calcium ion concentration; B cell receptor signaling pathway; transitional one stage B cell differentiation; Bergmann glial cell differentiation; collateral sprouting; negative regulation of mitotic cell cycle; cell adhesion; neuromuscular process controlling balance; positive regulation of oxidoreductase activity; B cell proliferation during immune response; epidermal growth factor receptor signaling pathway; spleen development; cell migration; positive regulation of I-kappaB kinase/NF-kappaB cascade; thymus development; activated T cell proliferation; B-1 B cell homeostasis; DNA damage response, signal transduction; endocytosis; negative regulation of I-kappaB kinase/NF-kappaB cascade; DNA repair; phagocytosis; positive regulation of peptidyl-tyrosine phosphorylation; regulation of actin cytoskeleton organization and biogenesis; positive regulation of osteoblast proliferation; microspike biogenesis; negative regulation of ubiquitin-protein ligase activity; autophagy; innate immune response; positive regulation of release of sequestered calcium ion into cytosol; response to oxidative stress; negative regulation of cell-cell adhesion; actin cytoskeleton organization and biogenesis; response to DNA damage stimulus; phosphorylation
Product References and Citations for anti-Abl1 antibody
Ko, H.S., et al. Proc. Natl. Acad. Sci. U.S.A. 107(38):16691-16696(2010)
Yamaguchi, T., et al. Apoptosis 15(8):927-935(2010)
Michael, M., et al. Curr. Biol. 20(9):783-791(2010)
Swimm, A.I., et al. J. Virol. 84(9):4243-4251(2010)
de Arce, K.P., et al. J. Neurosci. 30(10):3728-3738(2010)

Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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