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anti-AQP4 antibody :: Rabbit anti-Mouse Aquaporin 4 (AQP4) Polyclonal Antibody

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Catalog # MBS2004472 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
  0.01 mg  /  $105 +1 FREE 8GB USB
  0.02 mg  /  $125 +1 FREE 8GB USB
  0.05 mg  /  $170 +1 FREE 8GB USB
  0.1 mg  /  $210 +1 FREE 8GB USB
  0.2 mg  /  $315 +1 FREE 8GB USB
  1 mg  /  $745 +1 FREE 8GB USB
Product Name

Aquaporin 4 (AQP4), Polyclonal Antibody

Popular Item
Also Known As

Polyclonal Antibody to Aquaporin 4 (AQP4)

Matching Pairs
Unconjugated Antibody: Aquaporin 4 (AQP4) (MBS2004472)
Biotin Conjugated Antibody: Aquaporin 4 (AQP4) (MBS2003039)
Matching Pairs
Matching Pairs
Unconjugated Antibody: Aquaporin 4 (AQP4) (MBS2004472)
APC-CY7 Conjugated Antibody: Aquaporin 4 (AQP4) (MBS2044512)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
323
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF-SCDS KRTDVTGSIA LAIGFSVAIG HLFAINYTGA SMNPARSFGP AVIMGNWANH WIYWVGPIMG AVLAGALYEY VFCPDVELKR RLKEAFSKAA QQTKGSYMEV EDNRSQVETE DLILKPGVVH VIDI
3D Structure
ModBase 3D Structure for P55088
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Specificity
The antibody is a rabbit polyclonal antibody raised against AQP4. It has been selected for its ability to recognize AQP4 in immunohistochemical staining andwestern blotting.
Purity/Purification
Affinity Chromatography
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Concentration
200ug/ml (lot specific)
UOM
100ug
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2044514
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Other Notes
Small volumes of anti-AQP4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-AQP4 antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-AQP4 antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-AQP4 antibody
Western Blot: Sample: Mouse Heart Tissue.
anti-AQP4 antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-AQP4 antibody
Western Blot: Sample: Recombinant AQP4, Mouse.
anti-AQP4 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-AQP4 antibody
DAB staining on IHC-P; Samples: Mouse Brain Tissue
anti-AQP4 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-AQP4 antibody
DAB staining on IHC-P; Samples: Mouse Cerebrum Tissue)
anti-AQP4 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for AQP4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
37,977 Da
NCBI Official Full Name
aquaporin-4 isoform M23
NCBI Official Synonym Full Names
aquaporin 4
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
aquaporin-4
UniProt Protein Name
Aquaporin-4
UniProt Synonym Protein Names
Mercurial-insensitive water channel; MIWC; WCH4
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
AQP-4; MIWC  [Similar Products]
NCBI Summary for AQP4
This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015]
UniProt Comments for AQP4
AQP4: a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The predominant aquaporin found in brain. Two alternatively spliced transcript variants have been described

Protein type: Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family

Chromosomal Location of Human Ortholog: 18 A1|18 8.74 cM

Cellular Component: basal plasma membrane; basolateral plasma membrane; cell projection membrane; cytoplasm; external side of plasma membrane; integral component of membrane; integral component of plasma membrane; intercellular junction; membrane; plasma membrane; protein complex; sarcolemma; T-tubule

Molecular Function: identical protein binding; porin activity; protein binding; transporter activity; water channel activity

Biological Process: carbon dioxide transport; cellular response to glucose stimulus; cellular response to interferon-gamma; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 production; protein homooligomerization; regulation of vascular endothelial growth factor production; renal water absorption; sensory perception of sound; transport; water homeostasis; water transport
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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