NP_078809.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
carbohydrate sulfotransferase 5
NCBI Official Synonym Full Names
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
NCBI Official Synonym Symbols
gn6st-3; hIGn6ST; MGC74625; I-GlcNAc6ST; glcNAc6ST-3; I-GlcNAc-6-ST [Similar Products]
NCBI Protein Information
carbohydrate sulfotransferase 5; GST4-alpha; OTTHUMP00000174950; intestinal GlcNAc-6-sulfotransferase; N-acetylglucosamine 6-O-sulfotransferase 3; intestinal N-acetylglucosamine-6-O-sulfotransferase; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-alpha
UniProt Protein Name
Carbohydrate sulfotransferase 5
UniProt Synonym Protein Names
Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-alpha; GST4-alpha; Intestinal N-acetylglucosamine-6-O-sulfotransferase; I-GlcNAc6ST; Intestinal GlcNAc-6-sulfotransferase; hIGn6ST; N-acetylglucosamine 6-O-sulfotransferase 3
UniProt Entry Name
CHST5_HUMAN
NCBI Summary for CHST5
The carbohydrates of glycoconjugates are highly diverse structures with variation in monosaccharide composition, glycosidic linkage positions, and branching of chains. Further diversity is added by the covalent addition of sulfate moieties to particular hydroxyl groups and amino groups of saccharides. The sulfate modifications of glycoproteins can be extensive in amount and frequently occur at high density. They can have a profound effect on the physiochemical properties of the glycoconjugates, at least in part through the addition of negative charge. Carbohydrate sulfation plays a critical role in many biologic processes. CHST5 belongs to the GST family of sulfotransferases, which also includes CHST1 (MIM 603797), CHST2 (MIM 603798), CHST3 (MIM 603799), and LSST. These enzymes are 6-O-sulfotransferases, which add sulfate to C6 of galactose (Gal), N-acetylgalactosamine (GalNAc), or N-acetylglucosamine (GlcNAc) (Lee et al., 1999 [PubMed 10491328]).[supplied by OMIM]
UniProt Comments for CHST5
CHST5: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no activity toward keratan. Not involved in generating HEV-expressed ligands for SELL. Its substrate specificity may be influenced by its subcellular location. Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transferase; Membrane protein, integral; EC 2.8.2.-
Chromosomal Location of Human Ortholog: 16q22.3
Cellular Component: Golgi membrane; Golgi apparatus; intrinsic to Golgi membrane; integral to membrane
Molecular Function: sulfotransferase activity; N-acetylglucosamine 6-O-sulfotransferase activity
Biological Process: keratan sulfate metabolic process; sulfur metabolic process; glycosaminoglycan metabolic process; carbohydrate metabolic process; protein amino acid sulfation; keratan sulfate biosynthetic process; N-acetylglucosamine metabolic process; pathogenesis
Research Articles on CHST5
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Diseases associated with anti-CHST5 antibody
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