NP_064336.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,261 Da
NCBI Official Full Name
cardiotrophin-like cytokine factor 1 isoform 1
NCBI Official Synonym Full Names
cardiotrophin-like cytokine factor 1
NCBI Protein Information
cardiotrophin-like cytokine factor 1
UniProt Protein Name
Cardiotrophin-like cytokine factor 1
UniProt Synonym Protein Names
B-cell-stimulating factor 3; BSF-3; Novel neurotrophin-1; NNT-1
UniProt Synonym Gene Names
UniProt Comments for CLCF1
CLCF1: Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor. Defects in CLCF1 are the cause of cold-induced sweating syndrome type 2 (CISS2). Cold-induced sweating syndrome (CISS) is an autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Additional abnormalities include a high- arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Cytokine; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19|19 A
Cellular Component: extracellular region; intracellular
Molecular Function: ciliary neurotrophic factor receptor binding; cytokine activity; protein binding; protein heterodimerization activity; receptor binding
Biological Process: B cell differentiation; cell surface receptor linked signal transduction; JAK-STAT cascade; negative regulation of neuron apoptosis; positive regulation of astrocyte differentiation; positive regulation of B cell proliferation; positive regulation of cell proliferation; positive regulation of corticotropin-releasing hormone secretion; positive regulation of immunoglobulin production; positive regulation of isotype switching to IgE isotypes; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of protein kinase B signaling cascade
Research Articles on CLCF1
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Products associated with anti-CLCF1 antibody
Pathways associated with anti-CLCF1 antibody
Diseases associated with anti-CLCF1 antibody
Organs/Tissues associated with anti-CLCF1 antibody
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