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anti-CHRDL1 antibody :: Rabbit anti-Mouse Chordin Like Protein 1 Polyclonal Antibody

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Catalog # MBS2028812 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
  0.01 mg  /  $110 +1 FREE 8GB USB
  0.02 mg  /  $130 +1 FREE 8GB USB
  0.05 mg  /  $185 +1 FREE 8GB USB
  0.1 mg  /  $230 +1 FREE 8GB USB
  0.2 mg  /  $345 +1 FREE 8GB USB
  1 mg  /  $825 +1 FREE 8GB USB
Product Name

Chordin Like Protein 1 (CHRDL1), Polyclonal Antibody

Popular Item
Full Product Name

Polyclonal Antibody to Chordin Like Protein 1 (CHRDL1)

Matching Pairs
Matching Pairs
Matching Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q920C1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Specificity
The antibody is a rabbit polyclonal antibody raised against CHRDL1. It has beenselected for its ability to recognize CHRDL1 in immunohistochemical staining andwestern blotting.
Purity/Purification
Affinity Chromatography
Form/Format
Liquid
Concentration
200ug/ml (lot specific)
Fragment
CHRDL1 (Leu272~Cys447)
Organism Species
Mus musculus (Mouse)
Conjugate
No Conjugate
Immunogen
Recombinant CHRDL1 (Leu272~Cys447) expressed in E Coli.
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2076961
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-CHRDL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-CHRDL1 antibody
Applications Tested/Suitable for anti-CHRDL1 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)
Application Notes for anti-CHRDL1 antibody
Western blotting: 0.2-2ug/mL;1:250-2500
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-CHRDL1 antibody
Western Blot: Sample: Human 293T cell lysate; Primary Ab: 2ug/ml Rabbit Anti-Mouse CHRDL1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
anti-CHRDL1 antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-CHRDL1 antibody
Western Blot: Sample: Recombinant protein.
anti-CHRDL1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-CHRDL1 antibody
DAB staining on fromalin fixed paraffin- embedded brain tissue)
anti-CHRDL1 antibody Immunohistochemistry (IHC) (IHC) image
Knockout Validation of anti-CHRDL1 antibody
Knockout Validation: Lane 1: Wild-type 293T cell lysate; Lane 2: CHRDL1 knockout 293T cell lysate; Predicted MW: 51,37kd Observed MW: 40kd Primary Ab: 2ug/ml Rabbit Anti-Mouse CHRDL1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047)
anti-CHRDL1 antibody Knockout Validation image
NCBI/Uniprot data below describe general gene information for CHRDL1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
37,034 Da
NCBI Official Full Name
chordin-like protein 1 isoform 1
NCBI Official Synonym Full Names
chordin-like 1
NCBI Official Symbol
Chrdl1  [Similar Products]
NCBI Official Synonym Symbols
CHL; CHL1; VOPT; Nrln1
  [Similar Products]
NCBI Protein Information
chordin-like protein 1
UniProt Protein Name
Chordin-like protein 1
UniProt Synonym Protein Names
Neuralin-1; Neurogenesin-1; Ventroptin
Protein Family
UniProt Gene Name
Chrdl1  [Similar Products]
UniProt Synonym Gene Names
Ng1; Nrln1  [Similar Products]
UniProt Comments for CHRDL1
CHRDL1: Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation. May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development. Defects in CHRDL1 are the cause of megalocornea type 1, X-linked (MGC1). MGC1 is an eye disorder in which the corneal diameter is bilaterally enlarged (greater than 13 mm) without an increase in intraocular pressure. It may also be referred to as anterior megalophthalmos, since the entire anterior segment is larger than normal. Features of megalocornea in addition to a deep anterior chamber include astigmatic refractive errors, atrophy of the iris stroma, miosis secondary to decreased function of the dilator muscle, iridodonesis, and tremulousness, subluxation, or dislocation of the lens. Whereas most affected individuals exhibit normal ocular function, complications include cataract development and glaucoma following lenticular dislocation or subluxation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: X|X F2

Cellular Component: extracellular region

Biological Process: cell differentiation; cell fate determination; compound eye development; eye development; multicellular organism development; negative regulation of BMP signaling pathway; nervous system development; neuron differentiation; ossification
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-CHRDL1 antibody
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