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anti-EPOr antibody :: Sheep anti-Mouse EPOr Polyclonal Antibody

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Catalog # MBS534466
Unit / Price
  0.05 mg  /  $165 +1 FREE 8GB USB
anti-EPOr antibody
Product Name

EPOr, Polyclonal Antibody

Also Known As

EPOr antibody

Product Synonym Names
Polyclonal EPOr; Anti-EPOr; EPO Receptor; Erythropoietin Receptor
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
508
OMIM
133100
3D Structure
ModBase 3D Structure for P19235
Clonality
Polyclonal
Host
Sheep
Species Reactivity
Mouse
Specificity
Human
Form/Format
Purified serum supplied in 0.15M PBS, pH 7.4 with no preservatives added.
Biological Significance
The human erythropoietin receptor (EpoR) is located on stem and mature cells of the hematopoietic system. When activated by its native ligand, erythropoietin (Epo), EpoR mediates proliferation and maturation of the erythroid precursor cells leading to expansion of red cell populations.
Immunogen
EPOr antibody was raised in sheep using partial cDNA of the extracellular domain of human EpoR expressed as a GST fusion protein in E Coli as the immunogen.
Preparation and Storage
Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles.
Other Notes
Small volumes of anti-EPOr antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-EPOr antibody
Affinity purified Sheep polyclonal EPOr antibody
Applications Tested/Suitable for anti-EPOr antibody
ELISA (EIA), IC, Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-EPOr antibody
ELISA: 50 ng/ml, IC: 10 ug/ml, IHC: 10 ug/ml, IP: 10 ug/ml, WB: 10 ug/ml
NCBI/Uniprot data below describe general gene information for EPOr. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,809 Da
NCBI Official Full Name
erythropoietin receptor
NCBI Official Synonym Full Names
erythropoietin receptor
NCBI Official Symbol
NCBI Official Synonym Symbols
EPO-R
  [Similar Products]
NCBI Protein Information
erythropoietin receptor
UniProt Protein Name
Erythropoietin receptor
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
EPO-R  [Similar Products]
UniProt Entry Name
EPOR_HUMAN
NCBI Summary for EPOr
This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
UniProt Comments for EPOr
EPOR: erythropoietin receptor: a member of the cytokine receptor family. Mediates erythropoietin-induced erythroblast proliferation, differentiation and survival. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. Forms homodimers on EPO stimulation. Tyrosine-phosphorylated EpoR may bind several SH2 domain-containing proteins including LYN, the adapter protein APS, SHP-1, SHP-2, JAK2, PI3 kinases, STAT5A/B, SOCS3, and CRKL. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Three alternatively-spliced isoforms have been described. Isoform EPOR-T, missing the cytoplasmic tail, acts as a dominant-negative receptor of EPOR-mediated signaling.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 19p13.3-p13.2

Cellular Component: integral to plasma membrane; extracellular region

Molecular Function: identical protein binding; protein binding; erythropoietin receptor activity

Biological Process: heart development; decidualization; brain development; signal transduction

Disease: Erythrocytosis, Familial, 1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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