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anti-GLa antibody :: Rabbit anti-Mouse Galactosidase Alpha Polyclonal Antibody

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Catalog # MBS2026025 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
  0.01 mg  /  $105 +1 FREE 8GB USB
  0.02 mg  /  $125 +1 FREE 8GB USB
  0.05 mg  /  $170 +1 FREE 8GB USB
  0.1 mg  /  $210 +1 FREE 8GB USB
  0.2 mg  /  $315 +1 FREE 8GB USB
  1 mg  /  $745 +1 FREE 8GB USB
Product Name

Galactosidase Alpha (GLa), Polyclonal Antibody

Popular Item
Full Product Name

Polyclonal Antibody to Galactosidase Alpha (GLa)

Product Gene Name
Matching Pairs
Matching Pairs
Unconjugated Antibody: Galactosidase Alpha (MBS2026025)
APC-CY7 Conjugated Antibody: Galactosidase Alpha (GLa) (MBS2039276)
Matching Pairs
Unconjugated Antibody: Galactosidase Alpha (MBS2026025)
PE Conjugated Antibody: Galactosidase Alpha (GLa) (MBS2039277)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P51569
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Specificity
The antibody is a rabbit polyclonal antibody raised against GLa. It has beenselected for its ability to recognize GLa in immunohistochemical staining andwestern blotting.
Purity/Purification
Affinity Chromatography
Form/Format
Liquid
Concentration
200ug/ml (lot specific)
Fragment
GLa (Val29~Gly258)
Organism Species
Mus musculus (Mouse)
Conjugate
No Conjugate
Immunogen
Recombinant GLa (Val29~Gly258) expressed in E Coli.
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2039278
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-GLa antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-GLa antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)
Application Notes for anti-GLa antibody
Western blotting: 0.2-2ug/mL;1:250-2500
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-GLa antibody
Western Blot: Sample: Recombinant protein.
anti-GLa antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-GLa antibody
DAB staining on fromalin fixed paraffin-embedded Kidney tissue)
anti-GLa antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-GLa antibody
DAB staining on IHC-P; Samples: Mouse Testis Tissue)
anti-GLa antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for GLa. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
47,643 Da
NCBI Official Full Name
Alpha-galactosidase A
NCBI Official Synonym Full Names
galactosidase, alpha
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
alpha-galactosidase A
UniProt Protein Name
Alpha-galactosidase A
UniProt Synonym Protein Names
Alpha-D-galactosidase A; Alpha-D-galactoside galactohydrolase; Melibiase
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Comments for GLa
GLA: Defects in GLA are the cause of Fabry disease (FD). FD is a rare X-linked sphingolipidosis disease where glycolipid accumulates in many tissues. The disease consists of an inborn error of glycosphingolipid catabolism. FD patients show systemic accumulation of globotriaoslyceramide (Gb3) and related glycosphingolipids in the plasma and cellular lysosomes throughout the body. Clinical recognition in males results from characteristic skin lesions (angiokeratomas) over the lower trunk. Patients may show ocular deposits, febrile episodes, and burning pain in the extremities. Death results from renal failure, cardiac or cerebral complications of hypertension or other vascular disease. Heterozygous females may exhibit the disorder in an attenuated form, they are more likely to show corneal opacities. Belongs to the glycosyl hydrolase 27 family.

Protein type: Carbohydrate Metabolism - galactose; EC 3.2.1.22; Glycan Metabolism - glycosphingolipid biosynthesis - globo series; Hydrolase; Lipid Metabolism - glycerolipid; Lipid Metabolism - sphingolipid

Chromosomal Location of Human Ortholog: X E3|X 56.2 cM

Cellular Component: cytoplasm; extracellular region; extracellular space; Golgi apparatus; lysosome

Molecular Function: alpha-galactosidase activity; catalytic activity; galactoside binding; hydrolase activity; hydrolase activity, acting on glycosyl bonds; hydrolase activity, hydrolyzing O-glycosyl compounds; protein homodimerization activity; receptor binding

Biological Process: bone mineralization; carbohydrate metabolic process; glycoside catabolic process; glycosylceramide catabolic process; metabolic process; negative regulation of nitric oxide biosynthetic process; negative regulation of nitric-oxide synthase activity; oligosaccharide metabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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