NP_001300823.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,894 Da
NCBI Official Full Name
high mobility group protein B1
NCBI Official Synonym Full Names
high mobility group box 1
NCBI Protein Information
high mobility group protein B1
UniProt Protein Name
High mobility group protein B1
UniProt Synonym Protein Names
High mobility group protein 1; HMG-1
UniProt Synonym Gene Names
NCBI Summary for HMG1
This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]
UniProt Comments for HMG1
HMGB1: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Belongs to the HMGB family.
Protein type: DNA repair, damage; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 5 G3|5 89.18 cM
Cellular Component: cytoplasm; early endosome; extracellular region; extracellular space; neuron projection; nucleus
Molecular Function: bent DNA binding; calcium-dependent protein kinase regulator activity; crossed form four-way junction DNA binding; cytokine activity; double-stranded DNA binding; double-stranded RNA binding; open form four-way junction DNA binding; phosphatidylserine binding; protein binding; protein kinase activator activity; single-stranded RNA binding
Biological Process: base-excision repair; chromatin assembly; DNA geometric change; endothelial cell proliferation; eye development; induction of positive chemotaxis; inflammatory response; lung development; macrophage activation involved in immune response; myeloid dendritic cell activation; negative regulation of apoptotic cell clearance; plasmacytoid dendritic cell activation; positive regulation of cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of glycogen catabolic process; positive regulation of innate immune response; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-6 production; positive regulation of mesenchymal cell proliferation; positive regulation of mitotic cell cycle; positive regulation of myeloid cell differentiation; positive regulation of NIK/NF-kappaB signaling; positive regulation of protein phosphorylation; positive regulation of toll-like receptor 2 signaling pathway; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; positive regulation of wound healing; regulation of autophagy; regulation of nucleotide-excision repair; regulation of T cell mediated immune response to tumor cell; regulation of tolerance induction; response to glucocorticoid stimulus
Research Articles on HMG1
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Organs/Tissues associated with anti-HMG1 antibody
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