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anti-ITGA8 antibody :: Goat anti-Mouse Integrin alpha8 Polyclonal Antibody

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Catalog # MBS616970
Unit / Price
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  0.1 mg  /  $780 +1 FREE 8GB USB
anti-ITGA8 antibody
Product Name

Integrin alpha8 (ITGA8), Polyclonal Antibody

Full Product Name

Integrin alpha8

Product Synonym Names
Anti -Integrin alpha8
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 10; NC_000010.10 (15559088..15761770, complement). Location: 10p13
OMIM
604063
3D Structure
ModBase 3D Structure for P53708
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Mouse
Specificity
Recognizes mouse Integrin alpha8. Shows <1% crossreactivity with recombinant human and mouse Integrin alpha5 and recombinant human and mouse Integrin alphaV in direct ELISA and Western Blot. Species Sequence Homology: rat (96%), human (90%).
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 500ul sterile PBS.
Immunogen
Recombinant corresponding to Phe38-Phe1007 from mouse Integrin alpha8, expressed in CHO cells (NP_001001309).
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. 
Other Notes
Small volumes of anti-ITGA8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ITGA8 antibody
Integrin alpha8 is a 170-200kD member of the integrin family of adhesion molecules. It forms an exclusive noncovalent heterodimer with integrin beta-1. Alpha-8/beta-1 romotes both cell adhesion and survival and is known to bind to fibronectin, the latency-associated peptide in latent TGF-beta 1 and nephronectin. Mouse integrin alpha-8 is a 1025aa type I transmembrane glycoprotein. It contains a 969aa extracellular region (aa38-1006) and a 29aa cytoplasmic domain. One isoform may exist that shows a truncation after Ala675 of the precursor. In the ECD, mouse Integrin alpha8 shares 96% and 90% aa sequence identity with rat and human Integrin alpha-8 protein, respectively.
Product Categories/Family for anti-ITGA8 antibody
Applications Tested/Suitable for anti-ITGA8 antibody
ELISA (EL/EIA), Western Blot (WB), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)
Application Notes for anti-ITGA8 antibody
Suitable for use in Western Blot, Immunocytochemistry, Flow Cytometry and Direct ELISA.
Dilution: Western Blot: 0.1ug/ml
Immunocytochemistry: 5-15ug/ml used to detect Integrin alpha8 in immersion fixed 4T1 mouse mammary carcinoma cells.
Flow Cytometry: 2.5ug labels 10e6 4T1 mouse mammary carcinoma cells.
NCBI/Uniprot data below describe general gene information for ITGA8. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
117,474 Da[Similar Products]
NCBI Official Full Name
integrin alpha-8
NCBI Official Synonym Full Names
integrin, alpha 8
NCBI Official Symbol
ITGA8  [Similar Products]
NCBI Official Synonym Symbols
ITGA8
  [Similar Products]
NCBI Protein Information
integrin alpha-8; OTTHUMP00000019207
UniProt Protein Name
Integrin alpha-8
Protein Family
UniProt Gene Name
ITGA8  [Similar Products]
UniProt Entry Name
ITA8_HUMAN
NCBI Summary for ITGA8
Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014]
UniProt Comments for ITGA8
ITGA8: Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. Belongs to the integrin alpha chain family.

Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10p13

Cellular Component: cell surface; focal adhesion; apical part of cell; endoplasmic reticulum; postsynaptic density; plasma membrane; perikaryon; integrin complex

Molecular Function: metal ion binding

Biological Process: integrin-mediated signaling pathway; extracellular matrix organization and biogenesis; inner ear morphogenesis; cell-matrix adhesion; positive regulation of transforming growth factor beta receptor signaling pathway; mesodermal cell differentiation; memory; smooth muscle development; establishment of protein localization; cell-cell adhesion; cell projection organization and biogenesis; brain development; kidney development; metanephros development

Disease: Renal Hypodysplasia/aplasia 1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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