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anti-Jag1 antibody :: Rabbit anti-Mouse Jag1 Polyclonal Antibody

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Catalog # MBS9211581
Unit / Price
  0.08 mL  /  $165 +1 FREE 8GB USB
  0.4 mL  /  $370 +1 FREE 8GB USB
Western Blot (WB)
Product Name

Jag1, Polyclonal Antibody

Full Product Name

(Mouse) Jag1 Antibody (C-term)

Product Synonym Names
Protein jagged-1; Jagged1; CD339; Jag1
Antibody/Peptide Pairs
Jag1 peptide (MBS9229880) is used for blocking the activity of Jag1 antibody (MBS9211581)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9QXX0
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Mouse
Specificity
This Mouse Jag1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1191-1224 amino acids from the C-terminal region of Mouse Jag1.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-Jag1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Jag1 antibody
Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). May regulate fibroblast growth factor-induced angiogenesis.
Product Categories/Family for anti-Jag1 antibody
Applications Tested/Suitable for anti-Jag1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-Jag1 antibody
WB~~1:2000

Western Blot (WB) of anti-Jag1 antibody
Anti-Jag1 Antibody (C-term)at 1:2000 dilution + mouse brain lysates

Lysates/proteins at 20 ug per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution

Predicted band size : 134 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.
anti-Jag1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for Jag1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
134164
NCBI Official Full Name
protein jagged-1
NCBI Official Synonym Full Names
jagged 1
NCBI Official Symbol
NCBI Official Synonym Symbols
Htu; Ozz; ABE2; Ser-1; Gsfabe2
  [Similar Products]
NCBI Protein Information
protein jagged-1
UniProt Protein Name
Protein jagged-1
UniProt Synonym Protein Names
CD_antigen: CD339
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
Jagged1  [Similar Products]
UniProt Entry Name
JAG1_MOUSE
UniProt Comments for Jag1
JAG1: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Interacts with NOTCH2 and NOTCH3. Interacts with NOTCH1 (in the presence of calcium ions). Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.

Protein type: Membrane protein, integral

Cellular Component: membrane; apical part of cell; plasma membrane; integral to membrane

Molecular Function: protein binding; calcium ion binding; Notch binding

Biological Process: Notch signaling pathway; camera-type eye development; positive regulation of myeloid cell differentiation; T cell mediated immunity; multicellular organismal development; auditory receptor cell differentiation; negative regulation of fat cell differentiation; regulation of cell proliferation; positive regulation of osteoblast differentiation; organ morphogenesis; negative regulation of neuron differentiation; negative regulation of cell differentiation; response to muramyl dipeptide; morphogenesis of an epithelial sheet; blood vessel remodeling; cell communication; positive regulation of transcription from RNA polymerase II promoter; inner ear development; positive regulation of Notch signaling pathway
Product References and Citations for anti-Jag1 antibody
Shimizu K.,et al.J. Biol. Chem. 274:32961-32969(1999).
Loomes K.M.,et al.Hum. Mol. Genet. 8:2443-2449(1999).

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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