AAD14361.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,848 Da
NCBI Official Full Name
monoamine oxidase A, partial
NCBI Official Synonym Full Names
monoamine oxidase A
NCBI Official Synonym Symbols
NCBI Protein Information
amine oxidase [flavin-containing] A
UniProt Protein Name
Amine oxidase [flavin-containing] A
UniProt Synonym Protein Names
Monoamine oxidase type A; MAO-A
UniProt Synonym Gene Names
NCBI Summary for MAOA
This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
UniProt Comments for MAOA
MAOA: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. Defects in MAOA are the cause of Brunner syndrome (BRUNS). Brunner syndrome is a form of X-linked non- dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior. Belongs to the flavin monoamine oxidase family.
Protein type: Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - glycine, serine and threonine; Amino Acid Metabolism - histidine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - tyrosine; EC 1.4.3.4; Membrane protein, integral; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450
Chromosomal Location of Human Ortholog: Xp11.3
Cellular Component: mitochondrial outer membrane; mitochondrion
Molecular Function: amine oxidase activity
Biological Process: biogenic amine metabolic process; dopamine catabolic process; neurotransmitter metabolic process
Disease: Brunner Syndrome
Research Articles on MAOA
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Products associated with anti-MAOA antibody
Pathways associated with anti-MAOA antibody
Diseases associated with anti-MAOA antibody
Organs/Tissues associated with anti-MAOA antibody
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