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anti-NRF1 antibody :: Rabbit anti-Mouse Nuclear Respiratory Factor 1 Polyclonal Antibody

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Catalog # MBS622365
Unit / Price
  0.05 mg  /  $695 +1 FREE 8GB USB
anti-NRF1 antibody
Product Name

Nuclear Respiratory Factor 1 (NRF1), Polyclonal Antibody

Also Known As

Nuclear Respiratory Factor 1 (NRF1, NRF-1, Alpha-PAL, EWG)

Product Synonym Names
Anti -Nuclear Respiratory Factor 1 (NRF1, NRF-1, Alpha-PAL, EWG)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 7; NC_000007.13 (129251555..129396922). Location: 7q32
OMIM
600879
3D Structure
ModBase 3D Structure for Q16656
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse
Specificity
Recognizes Mouse Nuclear Respiratory Factor 1 (NRF1). Species Crossreactivity: Mouse.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide.
Immunogen
Synthetic peptide, KLH-conjugated. Epitope: Purified recombinant mouse NRF1 protein corresponding to aa 1- 534 of the native protein.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-NRF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-NRF1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-NRF1 antibody
Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: Immunohistochemistry: 2-5ug/ml
ELISA: 1:3000-1:10,000
Western Blot: 1:500-1:2000
NCBI/Uniprot data below describe general gene information for NRF1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,541 Da[Similar Products]
NCBI Official Full Name
nuclear respiratory factor 1
NCBI Official Synonym Full Names
nuclear respiratory factor 1
NCBI Official Symbol
NCBI Official Synonym Symbols
ALPHA-PAL
  [Similar Products]
NCBI Protein Information
nuclear respiratory factor 1; NRF-1; OTTHUMP00000184912; OTTHUMP00000184913; OTTHUMP00000184914; alpha palindromic-binding protein
UniProt Protein Name
Nuclear respiratory factor 1
UniProt Synonym Protein Names
Alpha palindromic-binding protein
UniProt Gene Name
UniProt Entry Name
NRF1_HUMAN
NCBI Summary for NRF1
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq]
UniProt Comments for NRF1
NRF1: Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. Belongs to the NRF1/Ewg family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 7q32

Cellular Component: nucleoplasm; cytoplasm

Biological Process: mitochondrion organization and biogenesis; generation of precursor metabolites and energy; organ regeneration; transcription, DNA-dependent; organelle organization and biogenesis; response to lipopolysaccharide; cellular lipid metabolic process; response to estradiol stimulus; regulation of transcription from RNA polymerase II promoter; response to folic acid; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; response to electrical stimulus
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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